AB108456

Anti-Somatostatin 抗体

Name: Anti-Somatostatin 抗体 (ab108456) | Abcam
Brand: Abcam Limited
SKU: AB108456
Price: 65000 JPY
Availability: InStock
Rating: 5 (5 reviews)

Anti-Somatostatin antibody

BOND RX™ Validated
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(5 Reviews)

(23 Publications)

Anti-Somatostatin antibody (ab108456) is a rabbit polyclonal antibody detecting Somatostatin in IHC-P. Suitable for Human, Mouse, Rat.

- Over 10 publications

別名を表示する

Somatostatin, Growth hormone release-inhibiting factor, SST

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

IHC image of Somatostatin staining in a section of formalin-fixed paraffin-embedded normal rat pancreas performed on a Leica BOND™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20mins. The section was then incubated with ab108456, 1ug/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset secondary-only control image is taken from an identical assay without primary antibody.
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

IHC image of Somatostatin staining in Human normal pancreas formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab108456, 5μg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

IHC image of Somatostatin staining in a section of formalin-fixed paraffin-embedded normal mouse pancreas performed on a Leica BOND™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6, epitope retrieval solution 1) for 20mins. The section was then incubated with ab108456, 1ug/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

The inset secondary-only control image is taken from an identical assay without primary antibody.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Human, Rat

アプリケーション

IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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製品の詳細

What is this antibody validated in?
Anti-Somatostatin antibody (ab108456) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples.

Trusted by the scientific community
Anti-Somatostatin (ab108456) was first used in a scientific publication in 2012 and has been cited over 10 times in peer-reviewed journals.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Somatostatin also known as growth hormone-inhibiting hormone (GHIH) is a peptide hormone with a molecular mass around 3200 Daltons. This protein is expressed mainly in the central nervous system including the hypothalamus as well as in the pancreas and gastrointestinal tract. Somatostatin consists of two biologically active forms: one with 14 amino acids and another with 28 amino acids. This target exerts its mechanical function by binding to specific G-protein-coupled somatostatin receptors leading to inhibition of various signaling pathways.

Biological function summary

Somatostatin regulates the endocrine system and affects neurotransmission and cell proliferation. It inhibits the secretion of several hormones such as growth hormone thyroid-stimulating hormone and insulin. Somatostatin also plays a role in reducing gastric acid secretion and slowing down gastrointestinal motility. While somatostatin does not act as part of a larger complex its action is highly localized in the tissues where it is produced and released.

Pathways

Somatostatin acts significantly in both the growth hormone and insulin signaling pathways. In the growth hormone pathway it serves as a counter-regulatory hormone to growth hormone-releasing hormone (GHRH) therefore controlling growth hormone levels. In the insulin signaling pathway somatostatin interacts with insulin and glucagon modulating glucose metabolism. It is also related to other proteins like cortistatin which shares similar functions and can bind to the same receptors.

Somatostatin is linked with conditions such as acromegaly and diabetes. In acromegaly excessive growth hormone production occurs due to reduced somatostatin activity making somatostatin analogs a therapeutic option. Meanwhile in diabetes altered somatostatin levels can influence insulin and glucagon balance affecting glucose homeostasis. Somatostatin’s interaction with its receptors and proteins like insulin plays an important role in the management of these conditions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Somatostatin-14. Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.. Neuronostatin. May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed : 29615476).

See full target information Somatostatin

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文献 (23)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:5110 PubMed40467586

2025

FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction.

Applications

Unspecified application

Species

Unspecified reactive species

Clarissa Tacto,Meghan Tahbaz,Andrew Salib,Shudi Wang,Fritz Cayabyab,Jinhyuk Choi,Kiyoka Kim,Yu Hamba,Harvey Perez,Paul D Gershon,Robert Damoiseaux,Tae Gyu Oh,Eiji Yoshihara

Biological research 57:46 PubMed39014514

2024

Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology.

Applications

Unspecified application

Species

Unspecified reactive species

Camila de Ávila,Anna Gugula,Aleksandra Trenk,Anthony J Intorcia,Crystal Suazo,Jennifer Nolz,Julie Plamondon,Divyanshi Khatri,Lauren Tallant,Alexandre Caron,Anna Blasiak,Geidy E Serrano,Thomas G Beach,Andrew L Gundlach,Diego F Mastroeni

Molecular neurobiology 61:6968-6983 PubMed38363536

2024

GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer A Cale,Ethan J Chauhan,Joshua J Cleaver,Anthoio R Fusciardi,Sophie McCann,Hannah C Waters,Juš Žavbi,Madeleine V King

iScience 27:108802 PubMed38318380

2024

Characterization of metabolic alterations in the lean metabolically unhealthy alpha defensin transgenic mice.

Applications

Unspecified application

Species

Unspecified reactive species

Abd Al-Roof Higazi,Emad Maraga,Saja Baraghithy,Shiran Udi,Shahar Azar,Ann Saada,Benjamin Glaser,Dana Avrahami,Suhair Abdeen,Zenab Hamdan,Joseph Tam,Rami Abu Fanne

Cell 186:4365-4385.e27 PubMed37774677

2023

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology.

Applications

Unspecified application

Species

Unspecified reactive species

Hansruedi Mathys,Zhuyu Peng,Carles A Boix,Matheus B Victor,Noelle Leary,Sudhagar Babu,Ghada Abdelhady,Xueqiao Jiang,Ayesha P Ng,Kimia Ghafari,Alexander K Kunisky,Julio Mantero,Kyriaki Galani,Vanshika N Lohia,Gabrielle E Fortier,Yasmine Lotfi,Jason Ivey,Hannah P Brown,Pratham R Patel,Nehal Chakraborty,Jacob I Beaudway,Elizabeth J Imhoff,Cameron F Keeler,Maren M McChesney,Haishal H Patel,Sahil P Patel,Megan T Thai,David A Bennett,Manolis Kellis,Li-Huei Tsai

Neuron 111:2863-2880.e6 PubMed37451263

2023

Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period.

Applications

Unspecified application

Species

Unspecified reactive species

Nazim Kourdougli,Anand Suresh,Benjamin Liu,Pablo Juarez,Ashley Lin,David T Chung,Anette Graven Sams,Michael J Gandal,Verónica Martínez-Cerdeño,Dean V Buonomano,Benjamin J Hall,Cédric Mombereau,Carlos Portera-Cailliau

Data in brief 48:109213 PubMed37383828

2023

Experimental datasets on the immunohistological assessment of δ-cells in the islet organs of the endocrine pancreas of Japanese medaka () fish exposed to graphene oxide.

Applications

Unspecified application

Species

Unspecified reactive species

Asok K Dasmahapatra,Paul B Tchounwou

Frontiers in neuroscience 17:1169927 PubMed37250409

2023

Glutamatergic neurons and GABAergic neurons of medial prefrontal cortex control hoarding-like behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Xiong,Beining Wang,Yunxia Shang,Huan Liu,Zihao Zhan,Qi Xu,Kai Wang,Zhi Zhang,Tingting Sun

Proceedings of the National Academy of Sciences of the United States of America 120:e2221686120 PubMed37014857

2023

Mutant β-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Dong,Louis J Ptáček,Ying-Hui Fu

Ecotoxicology and environmental safety 253:114649 PubMed36806823

2023

Evaluation of pancreatic δ- cells as a potential target site of graphene oxide toxicity in Japanese medaka (Oryzias latipes) fish.

Applications

Unspecified application

Species

Unspecified reactive species

Asok K Dasmahapatra,Paul B Tchounwou

View all publications

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Abcam product promise

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Anti-Somatostatin 抗体

Anti-Somatostatin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (23)

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Abcam product promise