Anti-Sodium/Hydrogen Exchanger 1/NHE-1 抗体 [4E9] (ab24018)
Key features and details
- Mouse monoclonal [4E9] to Sodium/Hydrogen Exchanger 1/NHE-1
- Suitable for: WB
- Reacts with: Human, Pig
- Isotype: IgG1
製品の概要
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製品名
Anti-Sodium/Hydrogen Exchanger 1/NHE-1 antibody [4E9]
Sodium/Hydrogen Exchanger 1/NHE-1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [4E9] to Sodium/Hydrogen Exchanger 1/NHE-1 -
由来種
Mouse -
特異性
Na+/H+ exchanger, isoform NHE1. -
アプリケーション
適用あり: WBmore details
適用なし: IHC-Fr,IHC-P or IP -
種交差性
交差種: Human, Pig -
免疫原
Fusion protein corresponding to Pig Sodium/Hydrogen Exchanger 1/NHE-1 (C terminal).
Database link: P48762 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: 0.0268% PBS, 1.45% Sodium chloride -
Concentration information loading... -
精製度
Tissue culture supernatant -
特記事項（精製）
Purified immunoglobulin from culture supernatant. -
ポリ/モノ
モノクローナル -
クローン名
4E9 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab24018の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. -
組織特異性
Kidney and intestine. -
配列類似性
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. -
翻訳後修飾
Phosphorylated upon DNA damage, probably by ATM or ATR.
O-glycosylated. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6548 Human
- Entrez Gene: 397458 Pig
- Omim: 107310 Human
- SwissProt: P19634 Human
- SwissProt: P48762 Pig
- Unigene: 469116 Human
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別名
- amiloride-sensitive antibody
- APNH antibody
- APNH1 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab24018 は 1 報の論文で使用されています。
- Busco G et al. NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space. FASEB J 24:3903-15 (2010). WB ; Human . PubMed: 20547664