Anti-SNAP25 (phospho S187) 抗体 (ab169871)
Key features and details
- Rabbit polyclonal to SNAP25 (phospho S187)
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-SNAP25 (phospho S187) antibody
SNAP25 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SNAP25 (phospho S187) -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat
交差が予測される動物種: Mouse, Guinea pig, Human, Non human primates, Zebrafish
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免疫原
Synthetic peptide within Rat SNAP25 (phospho S187). The exact sequence is proprietary. Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser187 conjugated to KLH
Database link: P60881 -
ポジティブ･コントロール
- Rat hippocampal lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.50
Constituents: 50% Glycerol, 0.88% Sodium chloride, 0.01% BSA, 0.24% HEPES -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab169871の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/1000. Predicted molecular weight: 23 kDa.
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| 特記事項 |
|---|
|
WB
1/1000. Predicted molecular weight: 23 kDa. |
ターゲット情報
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機能
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. -
組織特異性
Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum. -
配列類似性
Belongs to the SNAP-25 family.
Contains 2 t-SNARE coiled-coil homology domains. -
翻訳後修飾
Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association. -
細胞内局在
Cytoplasm > perinuclear region. Cell membrane. Cell junction > synapse > synaptosome. Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. - Information by UniProt
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参照データベース
- Entrez Gene: 6616 Human
- Entrez Gene: 20614 Mouse
- Entrez Gene: 25012 Rat
- Entrez Gene: 30712 Zebrafish
- Omim: 600322 Human
- SwissProt: P60880 Human
- SwissProt: P60879 Mouse
- SwissProt: P60881 Rat
see all -
別名
- bA416N4.2 antibody
- Bdr antibody
- CMS18 antibody
see all
画像
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Western blot - Anti-SNAP25 (phospho S187) antibody (ab169871)All lanes : Anti-SNAP25 (phospho S187) antibody (ab169871) at 1/1000 dilution
Lane 1 : Rat hippocampal lysate
Lane 2 : Rat hippocampal lysate treated with Lambda phosphatase (400 units/100 µl lysate for 30 min)
Predicted band size: 23 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab169871 は 2 報の論文で使用されています。
- Fan S et al. Ceftriaxone Suppresses Group II Metabotropic Glutamate Receptor Expression Contributing to Reversal of Recognition Memory Deficits of Amyloid Precursor Protein/Presenilin 1 AD Mice. Front Neurosci 16:905403 (2022). PubMed: 35860293
- Wang X et al. Phosphorylated SNAP25 in the CA1 regulates morphine-associated contextual memory retrieval via increasing GluN2B-NMDAR surface localization. Addict Biol 23:1067-1078 (2018). PubMed: 28884870