AB4114

Anti-SNAP23 抗体

Name: Anti-SNAP23 抗体 (ab4114) | Abcam
Brand: Abcam Limited
SKU: AB4114
Price: 85000 JPY
Availability: InStock
Rating: 4 (2 reviews)

Anti-SNAP23 antibody

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(2 Reviews)

(25 Publications)

Rabbit Polyclonal SNAP23 antibody. Suitable for IHC-P, IP, WB, ICC/IF, IHC-Fr and reacts with Human, Mouse, Rat samples. Cited in 25 publications. Immunogen corresponding to Recombinant Protein within Human Synaptosomal-associated protein 23.

別名を表示する

Synaptosomal-associated protein 23, SNAP-23, Vesicle-membrane fusion protein SNAP-23, SNAP23

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNAP23 antibody (AB4114)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNAP23 antibody (AB4114)

IHC image of ab4114 staining in human placenta tissue formalin fixed paraffin embedded tissue section, performed on a Leica Bond^TM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab4114, 1μg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human, Rat, Mouse

アプリケーション

IP, IHC-Fr, ICC/IF, WB, IHC-P

applications

免疫原

Recombinant Protein within Human Synaptosomal-associated protein 23. The exact immunogen used to generate this antibody is proprietary information.

O00161

特異性

This antibody reacts specifically with human SNAP23.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Whole antiserum

バッファー組成

Constituents: Whole serum

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SNAP23 also known as Synaptosomal-Associated Protein 23 is an important component in the mechanism of vesicular trafficking. It has a molecular mass of approximately 23 kDa and functions as a t-SNARE (target membrane SNAP receptor) protein. SNAP23 is expressed in various tissues with high expression levels in the brain pancreas liver and adipose tissue. This protein facilitates the fusion of vesicles with target membranes by forming SNARE complexes which are essential for the exocytosis and endocytosis processes.

Biological function summary

SNAP23 plays a significant role in the regulation of membrane fusion events and intracellular transport. It forms part of the SNARE complex which includes v-SNAREs on vesicle membranes and other t-SNAREs on target membranes. This complex orchestrates the docking and fusion of vesicles enabling the release of neurotransmitters and other cargoes in neuronal and non-neuronal cells. By mediating these events SNAP23 is important for neurotransmission insulin-regulated glucose uptake and other cellular processes.

Pathways

SNAP23 functions in the exocytotic and endocytic pathways where it aids in the accurate secretion and recycling of cellular components. It interacts with proteins like Syntaxin and VAMP (vesicle-associated membrane protein) to achieve precise vesicle targeting and fusion. SNAP23 is also implicated in insulin-signaling pathways where it modulates GLUT4 translocation to the cell surface a process vital for maintaining glucose homeostasis. These interactions underline its involvement in both neural communication and metabolic regulation.

SNAP23 has been associated with metabolic conditions such as type 2 diabetes and neurological disorders. The protein's function in insulin-regulated glucose transport suggests its relevance in diabetes where impaired glucose uptake occurs. In neurological contexts alterations in SNAP23 expression or function might contribute to disorders affecting synaptic transmission. Additionally its connection with proteins like GLUT4 and VAMP highlights SNAP23's role in disease contexts providing a linkage between vesicular transport and disease pathology.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

See full target information Synaptosomal-associated protein 23

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文献 (25)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Cell physiology 328:C429-C439 PubMed39726261

2024

Syntaxin 4-enhanced plasma membrane repair is independent of dysferlin in skeletal muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Hsin-Yu Chen,Daniel E Michele

Cell discovery 10:121 PubMed39648224

2024

Packaged release and targeted delivery of cytokines by migrasomes in circulation.

Applications

Unspecified application

Species

Unspecified reactive species

Haifeng Jiao,Xiaopeng Li,Ying Li,Ziyi Guo,Yuzhuo Yang,Yiqun Luo,Xiaoyu Hu,Li Yu

Molecular cancer research : MCR 20:434-445 PubMed34876482

2021

Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking.

Applications

Unspecified application

Species

Unspecified reactive species

Megan I Brasher,Shawn C Chafe,Paul C McDonald,Oksana Nemirovsky,Genya Gorshtein,Zachary J Gerbec,Wells S Brown,Olivia R Grafinger,Matthew Marchment,Esther Matus,Shoukat Dedhar,Marc G Coppolino

Journal of experimental & clinical cancer research : CR 40:183 PubMed34088337

2021

LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation.

Applications

Unspecified application

Species

Unspecified reactive species

Xueqiang Peng,Xinyu Li,Shuo Yang,Mingyao Huang,Shibo Wei,Yingbo Ma,Yan Li,Bo Wu,Hongyuan Jin,Bowen Li,Shilei Tang,Qing Fan,Jingang Liu,Liang Yang,Hangyu Li

Cell death discovery 7:112 PubMed34001861

2021

Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Luomeng Qian,Xiaoshan Yang,Shaohui Li,Hang Zhao,Yunge Gao,Shuhui Zhao,Xiaohui Lv,Xiyuan Zhang,Lingxia Li,Lianghao Zhai,Fuxing Zhou,Biliang Chen

Journal of experimental & clinical cancer research : CR 40:98 PubMed33722248

2021

Long non-coding RNA NORAD promotes the prostate cancer cell extracellular vesicle release via microRNA-541-3p-regulated PKM2 to induce bone metastasis of prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chuan-Yi Hu,Juan Chen,Xin-Hua Qin,Pan You,Jie Ma,Jing Zhang,He Zhang,Ji-Dong Xu

Toxins 12: PubMed33352834

2020

Engineering an Effective Human SNAP-23 Cleaving Botulinum Neurotoxin A Variant.

Applications

Unspecified application

Species

Unspecified reactive species

Stefan Sikorra,Sarah Donald,Mark Elliott,Susan Schwede,Shu-Fen Coker,Adam P Kupinski,Vineeta Tripathi,Keith Foster,Matthew Beard,Thomas Binz

Cell reports 29:3958-3973.e7 PubMed31851926

2019

Dynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche.

Applications

Unspecified application

Species

Unspecified reactive species

Virginie Stévenin,Yuen-Yan Chang,Yoann Le Toquin,Magalie Duchateau,Quentin Giai Gianetto,Chak Hon Luk,Audrey Salles,Victoria Sohst,Mariette Matondo,Norbert Reiling,Jost Enninga

Biology open 8: PubMed31142470

2019

Acid Sphingomyelinase regulates the localization and trafficking of palmitoylated proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Xiahui Xiong,Chia-Fang Lee,Wenjing Li,Jiekai Yu,Linyu Zhu,Yongsoon Kim,Hui Zhang,Hong Sun

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33:1389-1400 PubMed30133326

2018

Plasma membrane cholesterol trafficking in steroidogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Bing Deng,Wen-Jun Shen,Dachuan Dong,Salman Azhar,Fredric B Kraemer

View all publications

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Abcam product promise

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Anti-SNAP23 抗体

Anti-SNAP23 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNAP23 antibody (AB4114)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (25)

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