AB11083

Anti-Slow Skeletal Myosin Heavy chain 抗体 [NOQ7.5.4D]

Name: Anti-Slow Skeletal Myosin Heavy chain 抗体 [NOQ7.5.4D] (ab11083) | Abcam
Brand: Abcam Limited
SKU: AB11083
Rating: 5 (14 reviews)

Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D]

(14 Reviews)

(144 Publications)

Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (ab11083) is a mouse monoclonal antibody detecting Slow Skeletal Myosin Heavy chain in Western Blot, IHC-P. Suitable for Rabbit, Rat.

- Over 110 publications
- Trusted since 2004

別名を表示する

MYHCB, MYH7, Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, MyHC-beta

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

IHC-P

AbReview45619****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

ab11083 at 1/500 dilution, staining Slow Skeletal Myosin Heavy chain in mouse tissue sections by Immunohistochemistry (Formalin/PFA-fixed paraffin embedded sections).

Supplier Data

Western blot - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

Lane 1:

Western blot - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (ab11083) at 1.25 µg/mL

Lane 2:

Western blot - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (ab11083) at 2.5 µg/mL

Lane 3:

Negative control antibody

All lanes:

Rat skeletal muscle

Secondary

All lanes:

Anti-Mouse IgG (Fac-specific)-peroxidase conjugate at 1/5000 dilution

Predicted band size: 223 kDa

false

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded rabbit tomgue tissue staining Skeletal Myosin Heavy chain using ab11083 at 2.5 μg/mL.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

ab11083 at 1/4000 dilution, staining Slow Skeletal Myosin Heavy chain in rabbit tongue tissue section by Immunohistochemistry (Formalin/PFA-fixed paraffin embedded sections).

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

NOQ7.5.4D

アイソタイプ

IgG1

キャリアフリー

交差種

Rat, Rabbit

アプリケーション

IHC-P, WB

applications

免疫原

Native Full Length Protein corresponding to Human MYH7.

P12883

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Reactivity data

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製品の詳細

What is this antibody validated in?
Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (ab11083) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Rabbit, Rat samples.

What is the molecular weight of Slow Skeletal Myosin Heavy chain?
Anti-Slow Skeletal Myosin Heavy chain [NOQ7.5.4D] (ab11083) specifically detects a band for Slow Skeletal Myosin Heavy chain (UniProt: P12883) at a molecular weight of 200kDa.

Trusted by the scientific community
Anti-Slow Skeletal Myosin Heavy chain [NOQ7.5.4D] (ab11083) was first used in a scientific publication in 2004 and has been cited over 110 times in peer-reviewed journals.

Reviewed by scientists
Anti-Slow Skeletal Myosin Heavy chain [NOQ7.5.4D] (ab11083) has over 10 independent reviews from customers.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Proprietary technique

精製に関する特記事項

Purified from Tissue culture supernatant.

バッファー組成

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The slow skeletal myosin heavy chain also known as anti-slow or anti-sluggish is an essential protein component of muscle tissue. This protein is identified as MYH7 chain or type D chain with a molecular mass around 220 kDa. It is predominantly expressed in slow-twitch muscle fibers which are found in skeletal muscles responsible for enduring low-intensity (endurance) activities. Myosin staining techniques often highlight the distribution and density of these fibers in muscle tissues providing insights into fiber-type composition.

Biological function summary

This myosin heavy chain participates in muscle contraction by interacting with actin filaments forming cross-bridges through ATP-dependent mechanisms. As a part of the sarcomeric structure MYH7 works within the thick filament complex contributing to the contractile force of slow-twitch muscles. This particular myosin isoform is important for maintaining muscle stamina and efficiency over prolonged activities providing the necessary mechanical support for the generation of force at a lower contraction speed compared to fast-twitch fibers.

Pathways

The slow skeletal myosin heavy chain is integral to the calcium signaling pathway that regulates muscle contraction. This protein interacts with troponin and tropomyosin to modulate the actin-myosin interaction in a calcium-dependent manner. Additionally it plays a role in the heart muscle contraction pathway linking it to proteins such as actin which is important for cardiac function and rhythmic contraction.

Slow skeletal myosin heavy chain mutations are linked to cardiomyopathy particularly hypertrophic cardiomyopathy and dilated cardiomyopathy. These conditions compromise heart muscle function leading to symptoms such as fatigue and shortness of breath. The MYH7-associated disorder is often observed alongside alterations in other sarcomeric proteins like troponin T which further disrupts muscle contraction and cardiac output. Understanding these connections can aid in developing interventions and treatments for muscle-related diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.

See full target information MYH7

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文献 (144)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 13:1649640 PubMed40959669

2025

Decoding the prenatal clock of sheep muscle fiber type differentiation: a temporal map from embryonic to mature types.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenzhen Gu,Weiwei Duan,Chenxi Liu,Wenrong Li,Ning Zhang,Bin Han,Mingjun Liu

Frontiers in veterinary science 12:1637277 PubMed40808770

2025

miRNA-182-5p promotes myogenic differentiation of C2C12 cells via the suppression of ZBTB7A.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyuan Zhang,Yongheng Wang,Shan Shan,Siyu Liu

Journal of animal science and biotechnology 16:93 PubMed40598440

2025

Co-cultivation of Lactobacillus acidophilus and Bacillus subtilis mediates the gut-muscle axis affecting pork quality and flavor.

Applications

Unspecified application

Species

Unspecified reactive species

Zhixin Lin,Xinchen Zhou,Tingting Lu,Wendong An,Shenghao Chen,Suchen Li,Hui Miao,Xinyan Han

Stem cell research & therapy 16:336 PubMed40597262

2025

VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liu-Liu Shi,Yu-Ting Sun,Jia-Nan Sun,Jing Yue,Wei Chen,Kun Meng,Long Chen,Chang-Qing Hu,Rui Chen,Dong-Sheng Sun,Cheng-Bao Xu,Wei Yuan,Xin-Li Li,Dan Zhao,Yan Wu,Shi-Bing Xi,Xiao-Ying Zhao,Jun-Ming Tang

Poultry science 104:105419 PubMed40516297

2025

Developmental characteristics of skeletal muscle in goose during the embryonic and early post-hatching periods.

Applications

Unspecified application

Species

Unspecified reactive species

Kaiqi Weng,Yi Liu,Huiying Wang,Guohong Chen,Daqian He,Qi Xu

Animal nutrition (Zhongguo xu mu shou yi xue hui) 21:207-221 PubMed40487094

2025

Fibroblast growth factor 21/extracellular signal-regulated kinase 1/2 pathway as a key link mediates the effects of low-protein diet on skeletal muscle fiber type transformation in pigs.

Applications

Unspecified application

Species

Unspecified reactive species

Shuo Li,Pengbo Liang,Bo Wang,Jun Chen,Jinming You,Tiande Zou

Skeletal muscle 15:9 PubMed40128889

2025

Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers.

Applications

Unspecified application

Species

Unspecified reactive species

Oscar Horwath,Lucas Cornet,Henrik Strömlind,Marcus Moberg,Sebastian Edman,Karin Söderlund,Antonio Checa,Jorge L Ruas,Eva Blomstrand

Scientific reports 15:7384 PubMed40025125

2025

Remodeling of the cardiac striatin interactome and its dynamics in the diabetic heart.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Chacar,Wael Abdrabou,Cynthia Al Hageh,Liaqat Ali,Thenmozhi Venkatachalam,Pierre Zalloua,M-Saadeh Suleiman,Frank Christopher Howarth,Ali A Khraibi,Moni Nader

Animals : an open access journal from MDPI 15: PubMed39943074

2025

Effects of Free-Range Systems on Muscle Fiber Characteristics and Welfare Indicators in Geese.

Applications

Unspecified application

Species

Unspecified reactive species

Guoyao Wang,Jianzhou Chen,Yujiao Guo,Kaiqi Weng,Yu Zhang,Yang Zhang,Guohong Chen,Qi Xu,Yang Chen

Journal of cachexia, sarcopenia and muscle 16:e13693 PubMed39901373

2025

Nicotinamide Phosphoribosyltransferase Acetylation Mediating Muscle Dysfunction Contributes to Sleep Apnoea in Obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Liu Zhang,Ya Ru Yan,Shi Qi Li,Ying Ni Lin,Yi Wang,Yu Qing Wang,Ning Li,Fang Ying Lu,Xian Wen Sun,Li Yue Zhang,Jian Ping Zhou,Yong Jie Ding,Qing Yun Li

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Slow Skeletal Myosin Heavy chain 抗体 [NOQ7.5.4D]

Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

Western blot - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] (AB11083)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (144)

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