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AB226986

Anti-SLK 抗体

Anti-SLK antibody

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(1 Publication)

Rabbit Polyclonal SLK antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLK.

別名を表示する

KIAA0204, STK2, SLK, STE20-like serine/threonine-protein kinase, STE20-like kinase, hSLK, CTCL tumor antigen se20-9, STE20-related serine/threonine-protein kinase, Serine/threonine-protein kinase 2, STE20-related kinase

3 Images
Western blot - Anti-SLK antibody (AB226986)
  • WB

Supplier Data

Western blot - Anti-SLK antibody (AB226986)

5% SDS-PAGE gel.

All lanes:

Western blot - Anti-SLK antibody (ab226986) at 1/1000 dilution

Lane 1:

A549 (human lung carcinoma cell line) cell lysate at 30 µg

Lane 2:

H1299 cell lysate at 30 µg

Predicted band size: 143 kDa

false

Immunocytochemistry/ Immunofluorescence - Anti-SLK antibody (AB226986)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SLK antibody (AB226986)

4% paraformaldehyde-fixed H1299 cells stained for SLK (green) using ab226986 at 1/500 dilution in ICC/IF.

Blue : Hoechst 33342 staining.

Western blot - Anti-SLK antibody (AB226986)
  • WB

Lab

Western blot - Anti-SLK antibody (AB226986)

All lanes:

Western blot - Anti-SLK antibody (ab226986) at 1/1000 dilution

Lane 1:

WT 293T cell extracts at 30 µg

Lane 2:

SLK Knockout 293T cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 143 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human SLK. The exact immunogen used to generate this antibody is proprietary information.

Q9H2G2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SLK also known as Ste20-like kinase or STLK3 is a serine/threonine-protein kinase. It shows mechanical activity through phosphorylation of specific substrates facilitating cellular processes like migration and proliferation. SLK has an approximate mass of 140 kDa and predominantly occurs in various tissues including epithelial and neural tissues. Its expression is regulated by multiple factors contributing to its dynamic functional role in cells.
Biological function summary

SLK plays an essential role in regulating cytoskeletal organization and cell motility allowing rearrangement of actin fibers. It operates as part of a complex involved in signal transduction cascades that influence cellular shape and movement. This kinase modulates pathways important for cell cycle progression and apoptosis affecting cellular dynamics and integrity.

Pathways

SLK is integral to both the Rho and MAPK signaling pathways which are fundamental for cellular stress responses and growth signals. Within these pathways SLK interacts with proteins such as MINK1 and TAO1 contributing to the coordination of cellular responses to environmental changes and stress signals. SLK's role supports critical intracellular communications that decide cellular fate and adaptation processes.

SLK associates with cancer particularly in cases involving abnormal cell migration and metastasis. It interacts with proteins like the focal adhesion kinase (FAK) which strengthens its participation in oncogenic pathways. SLK also has links to neurodegenerative diseases where its deregulation affects cell survival and death pathways influencing disease progression due to its involvement with proteins like caspase-3 in apoptotic processes.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Mediates apoptosis and actin stress fiber dissolution.
See full target information SLK
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer management and research 12:9417-9428 PubMed33061629

2020

MicroRNA-139 Suppresses the Tumorigenicity of Triple Negative Breast Cancer Cells by Targeting SOX8.

Applications

Unspecified application

Species

Unspecified reactive species

Liangliang Dong,Dongmei Zhou,Chunxia Xin,Bing Liu,Ping Sun
View all publications
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