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AB67308

Anti-SLITRK4 抗体

Anti-SLITRK4 antibody

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(1 Publication)

Rabbit Polyclonal SLITRK4 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLITRK4.

別名を表示する

SLIT and NTRK-like protein 4, SLITRK4

1 Images
Western blot - Anti-SLITRK4 antibody (AB67308)
  • WB

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Western blot - Anti-SLITRK4 antibody (AB67308)

Lane 1:

Western blot - Anti-SLITRK4 antibody (ab67308) at 0.5 µg/mL

Lane 2:

Western blot - Anti-SLITRK4 antibody (ab67308) at 1 µg/mL

All lanes:

Mouse brain tissue lysate at 15 µg

Predicted band size: 94 kDa

Observed band size: 94 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human SLITRK4. The exact immunogen used to generate this antibody is proprietary information.

Q8IW52

特異性

ab67308 is predicted to have no cross-reactivity to other SLITRK proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SLITRK4 also known as SLIT and NTRK-like protein 4 is a protein involved in neural cell signaling. It is a member of the SLITRK family which consists of six known proteins that share structural similarities to both the Slit and Trk families of proteins. SLITRK4 has a molecular mass of approximately 104 kDa. This protein is highly expressed in the brain particularly in the thalamus region as well as in some other neural tissues. Its expression is less present in peripheral tissues indicating a more central nervous system-specific role.
Biological function summary

SLITRK4 plays an essential role in modulating synaptic activity and neuron-neuron communication. It is part of a transmembrane protein family interacting with other synaptic and intracellular proteins to coordinate signaling events that influence neuronal growth and connectivity. By regulating synaptic plasticity SLITRK4 contributes to the formation of functional neural circuits and is involved in the proper development and maintenance of synapses.

Pathways

SLITRK4 is integrally engaged in neurodevelopmental pathways particularly those governing neural circuit assembly and synaptic function. It interacts with proteins like leucine-rich repeat transmembrane neuronal proteins to facilitate synaptic adhesion and signaling processes. Additionally SLITRK4's role in synaptic modulation links it to pathways controlling neurotransmitter release and receptor signaling essential for effective communication between neurons.

SLITRK4 has shown associations with neurodevelopmental disorders such as schizophrenia and autism spectrum disorders. Disruptions in SLITRK4 can lead to misregulated synaptic function contributing to the pathophysiology of these conditions. Alterations in its expression or function may also affect interactions with related proteins like neurexins which are important for synaptic stability and network formation. Understanding these connections continues to provide insights into the molecular bases of these complex disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

It is involved in synaptogenesis and promotes synapse differentiation (PubMed : 27812321). Suppresses neurite outgrowth (By similarity).
See full target information SLITRK4
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 39:e104150 PubMed32347567

2020

Splice-dependent trans-synaptic PTPδ-IL1RAPL1 interaction regulates synapse formation and non-REM sleep.

Applications

Unspecified application

Species

Unspecified reactive species

Haram Park,Yeonsoo Choi,Hwajin Jung,Seoyeong Kim,Suho Lee,Hyemin Han,Hanseul Kweon,Suwon Kang,Woong Seob Sim,Frank Koopmans,Esther Yang,Hyun Kim,August B Smit,Yong Chul Bae,Eunjoon Kim
View all publications
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