JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB121737

Anti-SLFN13 抗体

Anti-SLFN13 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal SLFN13 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLFN13 aa 100-250.

別名を表示する

Schlafen family member 13, Schlafen-13, hSLFN13, SLFN13

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SLFN13 antibody (AB121737)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SLFN13 antibody (AB121737)

Immunofluorescent staining of Human cell line U-2 OS shows positivity in cytoplasm. Recommended concentration of ab121737 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLFN13 antibody (AB121737)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLFN13 antibody (AB121737)

ab121737 at 1/40 dilution staining SLFN13 in Paraffin-embedded Human Pancreas tissue by Immunohistochemistry. Note : strong cytoplasmic positivity in a subset of exocrine glandular cells.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human SLFN13 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q68D06

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SLFN13 also known as Schlafen family member 13 is a protein involved in various cellular processes. It has a molecular mass of about 86 kDa. This protein is mainly expressed in immune-related tissues including the spleen and lymph nodes. Mechanistically SLFN13 contains a unique SLFN domain and an ATP binding site suggesting a role in nucleic acid metabolism and possibly in regulating other processes within the cell.
Biological function summary

SLFN13 influences immune cell function and development. It is not part of a larger protein complex but it does interact with other cellular machinery involved in immune responses. Studies show SLFN13 modulates T-cell proliferation and influences inflammatory signaling pathways. This highlights its significance in coordinating immune responses during infections and immune challenges.

Pathways

SLFN13 takes part in the immune response signaling and inflammatory pathways. It interacts specifically in pathways like the interferon response and Th1 differentiation. Through these pathways SLFN13 connects with proteins such as STAT1 and IRF9 which play roles in activating the immune response when an organism faces pathogens.

SLFN13 holds relevance in autoimmune disorders and infectious diseases. Its altered expression levels can link to conditions such as systemic lupus erythematosus and viral infections where immune function is compromised or hyperactive. In these contexts SLFN13 influences or gets influenced by proteins like IFN-α and TNF-α which are critical in immune system regulation and chronic inflammation settings.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Endoribonuclease that cleaves tRNAs and rRNAs (PubMed : 29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed : 29563550). Does not act on tRNA(Sec) (PubMed : 29563550). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity (PubMed : 29563550).
See full target information SLFN13
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 7:15585 PubMed29138412

2017

Novel KIAA0753 mutations extend the phenotype of skeletal ciliopathies.

Applications

Unspecified application

Species

Unspecified reactive species

A Hammarsjö,Z Wang,R Vaz,F Taylan,M Sedghi,K M Girisha,D Chitayat,K Neethukrishna,P Shannon,R Godoy,K Gowrishankar,A Lindstrand,J Nasiri,M Baktashian,P T Newton,L Guo,W Hofmeister,M Pettersson,A S Chagin,G Nishimura,L Yan,N Matsumoto,A Nordgren,N Miyake,G Grigelioniene,S Ikegawa
View all publications
style
left-column
style
left-column
style
right-column

組合せ製品

Primary Antibodies

AB117803

Anti-ZNF687 antibody

Immunoprecipitation - Anti-ZNF687 antibody (AB117803)

  • 0
  • 0
Primary Antibodies

AB121173

Anti-ZNF589 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF589 antibody (AB121173)

  • 0
  • 0
Primary Antibodies

AB118800

Anti-ZZZ3 antibody

Western blot - Anti-ZZZ3 antibody (AB118800)

  • 0
  • 0
Primary Antibodies

AB121685

Anti-ZNF750 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF750 antibody (AB121685)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com