Anti-Six3 抗体 (ab172131)
Key features and details
- Mouse polyclonal to Six3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Six3 antibody
Six3 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to Six3 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow
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免疫原
Recombinant full length protein within Human Six3 aa 1 to the C-terminus. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: AAI53027.1 -
ポジティブ･コントロール
- Six3 transfected 293T cell line lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Constituent: 100% PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab172131の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (1) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa.
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| 特記事項 |
|---|
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. |
ターゲット情報
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機能
May be involved in visual system development. -
関連疾患
Defects in SIX3 are the cause of holoprosencephaly type 2 (HPE2) [MIM:157170]. Holoprosencephaly (HPE) [MIM:236100] is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. -
配列類似性
Belongs to the SIX/Sine oculis homeobox family.
Contains 1 homeobox DNA-binding domain. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 6496 Human
- Entrez Gene: 20473 Mouse
- Entrez Gene: 78974 Rat
- Omim: 603714 Human
- SwissProt: O95343 Human
- SwissProt: Q62233 Mouse
- Unigene: 567336 Human
- Unigene: 370208 Mouse
see all -
別名
- Homeobox protein SIX3 antibody
- HPE2 antibody
- Sine oculis homeobox homolog 3 antibody
see all
画像
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Western blot - Anti-Six3 antibody (ab172131)All lanes : Anti-Six3 antibody (ab172131) at 1 µg/ml
Lane 1 : Six3 transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 15 µl per lane.
Predicted band size: 35 kDa
データシートおよび資料
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Datasheet download
参考文献 (3)
ab172131 は 3 報の論文で使用されています。
- Liu S et al. TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-ß-catenin signaling. Aging (Albany NY) 12:25564-25580 (2020). PubMed: 33264103
- Liu Y et al. A novel rat model of ocular hypertension by a single intracameral injection of cross-linked hyaluronic acid hydrogel (Healaflow® ). Basic Clin Pharmacol Toxicol 127:361-370 (2020). PubMed: 32383327
- Li Y et al. Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells. J Biol Chem 292:19590-19604 (2017). PubMed: 28972157
