Anti-Sigma1-receptor 抗体 - C-terminal (ab53852)
Key features and details
- Rabbit polyclonal to Sigma1-receptor - C-terminal
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Sigma1-receptor antibody - C-terminal
Sigma1-receptor 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Sigma1-receptor - C-terminal -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat
交差が予測される動物種: Cow, Dog, Human, Mink
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免疫原
Synthetic peptide corresponding to Rat Sigma1-receptor (C terminal).
Database link: Q99720 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab53852の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (2) |
Use a concentration of 2 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).
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| 特記事項 |
|---|
|
WB
Use a concentration of 2 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa). |
ターゲット情報
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機能
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. -
組織特異性
Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. -
関連疾患
Amyotrophic lateral sclerosis 16, juvenile -
配列類似性
Belongs to the ERG2 family. -
細胞内局在
Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection > growth cone. Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. - Information by UniProt
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参照データベース
- Entrez Gene: 538903 Cow
- Entrez Gene: 481587 Dog
- Entrez Gene: 10280 Human
- Entrez Gene: 18391 Mouse
- Entrez Gene: 29336 Rat
- Omim: 601978 Human
- SwissProt: Q58DH7 Cow
- SwissProt: Q99720 Human
see all -
別名
- Aging associated gene 8 protein antibody
- Aging-associated gene 8 protein antibody
- AL024364 antibody
see all
画像
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Western blot - Anti-Sigma1-receptor antibody - C-terminal (ab53852)All lanes : Anti-Sigma1-receptor antibody - C-terminal (ab53852) at 2 µg/ml
Lane 1 : Mouse brain homogenate
Lane 2 : Rat liver homogenate
Lane 3 : Rat brain homogenate
Predicted band size: 25 kDa
Observed band size: 25 kDa
Additional bands at: 75 kDa. We are unsure as to the identity of these extra bands.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (34)
ab53852 は 34 報の論文で使用されています。
- Borroto-Escuela DO et al. Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes. Front Mol Neurosci 16:1106765 (2023). PubMed: 37293542
- Cui X et al. Starvation insult induces the translocation of high mobility group box 1 to cytosolic compartments in glioma. Oncol Rep 50:N/A (2023). PubMed: 37888772
- Shin SM et al. Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain. Gene Ther 29:1-15 (2022). PubMed: 32424233
- Song L et al. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat Cardiovasc Res 1:142-156 (2022). PubMed: 36051854
- Szabó Í et al. N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. Neuropharmacology 192:108612 (2021). PubMed: 34023338