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Anti-SIGLEC11 抗体 (ab106390)

Submit a review Submit a question References (1)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC11 antibody (ab106390)
  • Immunocytochemistry/ Immunofluorescence - Anti-SIGLEC11 antibody (ab106390)
  • Western blot - Anti-SIGLEC11 antibody (ab106390)

Key features and details

  • Rabbit polyclonal to SIGLEC11
  • Suitable for: ICC/IF, WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-SIGLEC11 antibody
    SIGLEC11 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to SIGLEC11

  • 由来種

    Rabbit

  • 特異性

    Specific to Human SIGLEC11, does not cross react with SIGLEC10.

  • アプリケーション

    適用あり: ICC/IF, WB, IHC-Pmore details

  • 種交差性

    交差種: Human

  • 免疫原

    18 amino acid peptide from near the carboxy terminus of Human SIGLEC11 (NP_443116).

  • ポジティブ･コントロール

    • HepG2 cell lysate Human liver tissue

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab106390の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
ICC/IF
Use a concentration of 20 µg/ml.
WB
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 76 kDa.
IHC-P
Use a concentration of 5 µg/ml.
特記事項
ICC/IF
Use a concentration of 20 µg/ml.
WB
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 76 kDa.
IHC-P
Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能

    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

  • 組織特異性

    Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

  • 配列類似性

    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • ドメイン

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

  • 翻訳後修飾

    Phosphorylated on tyrosine residues.

  • 細胞内局在

    Membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • sialic acid binding Ig like lectin 11 antibody
      • sialic acid binding lectin 11 antibody
      • Sialic acid-binding Ig-like lectin 11 antibody
      • Sialic acid-binding lectin 11 antibody
      • SIG11_HUMAN antibody
      • Siglec 11 antibody
      • Siglec-11 antibody
      • SIGLEC11 antibody
      see all

    画像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC11 antibody (ab106390)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC11 antibody (ab106390)
      ab106390 at 5µg/ml, staining SIGLEC11 in Human liver, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.
    • Immunocytochemistry/ Immunofluorescence - Anti-SIGLEC11 antibody (ab106390)
      Immunocytochemistry/ Immunofluorescence - Anti-SIGLEC11 antibody (ab106390)

      Immunofluorescence of SIGLEC11 in Human liver tissue with ab106390 at 20 ug/mL.

    • Western blot - Anti-SIGLEC11 antibody (ab106390)
      Western blot - Anti-SIGLEC11 antibody (ab106390)
      Anti-SIGLEC11 antibody (ab106390) at 1 µg/ml + HepG2 cell lysate at 15 µg

      Predicted band size: 76 kDa

    参考文献 (1)

    ab106390 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab106390 は 1 報の論文で使用されています。

    • Narta K  et al. Whole Exome Sequencing Reveals Novel Candidate Genes in Familial Forms of Glaucomatous Neurodegeneration. Genes (Basel) 14:N/A (2023). PubMed: 36833422

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