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AB228448

Anti-SIGLEC H 抗体 [ABM2B55]

Anti-SIGLEC H antibody [ABM2B55]

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(1 Publication)

Rat Monoclonal SIGLEC H antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication.

別名を表示する

SIGLEC like protein, Siglech, sialic acid binding Ig like lectin H

1 Images
Western blot - Anti-SIGLEC H antibody [ABM2B55] (AB228448)
  • WB

Supplier Data

Western blot - Anti-SIGLEC H antibody [ABM2B55] (AB228448)

All lanes:

Western blot - Anti-SIGLEC H antibody [ABM2B55] (ab228448) at 2 µg/mL

All lanes:

Mouse skeletal muscle lysate

Predicted band size: 34 kDa

false

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

ABM2B55

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Mouse

アプリケーション

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2-4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
Purified from TCS.
バッファー組成
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SIGLEC H also known as sialic acid-binding Ig-like lectin H weighs about 50 kDa. It is found on the surface of plasmacytoid dendritic cells (pDCs) and it is closely related to the immune system. This protein lacks a signaling domain but it can pair with other proteins to transmit signals across cell membranes. The expression of SIGLEC H is highly specific to pDCs making it a useful marker for these cells in various immunological studies.
Biological function summary

This protein plays an important role in the immune response. SIGLEC H functions in the recognition and uptake of pathogens through endocytosis by binding sialylated glycoproteins. Unlike some other members of the SIGLEC family it is not part of a complex and relies on interactions with other signaling molecules. These interactions facilitate phagocytosis and antigen presentation which are critical functions of pDCs in adaptive immunity.

Pathways

SIGLEC H becomes involved in the innate immune signaling pathways that regulate type I interferon production. The pathways include the Toll-like receptor (TLR) signaling pathway. SIGLEC H modulates TLR7 and TLR9 pathways in pDCs which manage the production of cytokines and chemokines. It can also influence the expression of interferon regulatory factors further impacting cytokine production and modulating immune response.

The improper function or regulation of SIGLEC H affects autoimmune diseases like systemic lupus erythematosus. Anomalies in SIGLEC H might also have implications for viral infections due to its role in pathogen detection and immune responses. Proteins such as TLR7 and interferon regulatory factor 7 (IRF7) show connections with SIGLEC H within these contexts often determining the outcome of immune-mediated and infectious diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information SIGLEC H
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文献 (1)

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Applications

Unspecified application

Species

Unspecified reactive species

Min Qin,Zhihai Liang,Heping Qin,Yifang Huo,Qing Wu,Huiying Yang,Guodu Tang
View all publications
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