Anti-SH3GL3 抗体 (ab184008)
Key features and details
- Rabbit polyclonal to SH3GL3
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-SH3GL3 antibody -
製品の詳細
Rabbit polyclonal to SH3GL3 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Recombinant fragment within Human SH3GL3 aa 73-305. The exact sequence is proprietary.
Database link: Q99963 -
ポジティブ･コントロール
- NT2D1, mouse brain and rat brain lysates.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab184008の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 39 kDa.
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| 特記事項 |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 39 kDa. |
ターゲット情報
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機能
Implicated in endocytosis. May recruit other proteins to membranes with high curvature. -
組織特異性
Brain and testis. -
配列類似性
Belongs to the endophilin family.
Contains 1 BAR domain.
Contains 1 SH3 domain. -
ドメイン
An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. -
細胞内局在
Cytoplasm. Early endosome membrane. Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons. - Information by UniProt
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参照データベース
- Entrez Gene: 6457 Human
- Entrez Gene: 20408 Mouse
- Entrez Gene: 81921 Rat
- Omim: 603362 Human
- SwissProt: Q99963 Human
- SwissProt: Q62421 Mouse
- SwissProt: O35180 Rat
- Unigene: 270055 Human
see all -
別名
- CNSA3 antibody
- EEN 2B L3 antibody
- EEN B2 antibody
see all
画像
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Western blot - Anti-SH3GL3 antibody (ab184008)Anti-SH3GL3 antibody (ab184008) at 1/1000 dilution + Mouse brain lysate at 50 µg
Predicted band size: 39 kDa12 % SDS PAGE
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Western blot - Anti-SH3GL3 antibody (ab184008)Anti-SH3GL3 antibody (ab184008) at 1/5000 dilution + Rat brain lysate at 50 µg
Predicted band size: 39 kDa12% SDS PAGE
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Western blot - Anti-SH3GL3 antibody (ab184008)Anti-SH3GL3 antibody (ab184008) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg
Predicted band size: 39 kDa12% SDS PAGE
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab184008 は 3 報の論文で使用されています。
- Nie Z et al. SH3GL3 acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling. Biochem Biophys Res Commun 544:73-80 (2021). PubMed: 33524871
- Kroll J et al. Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells. EMBO J 38:N/A (2019). PubMed: 30733243
- Poudel KR et al. Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Dev Cell 45:738-752.e6 (2018). PubMed: 29920278