JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB254666

Anti-SG2NA 抗体

Anti-SG2NA antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal SG2NA antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STRN3 aa 550 to C-terminus.

別名を表示する

GS2NA, SG2NA, STRN3, Striatin-3, Cell cycle autoantigen SG2NA, S/G2 antigen

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SG2NA antibody (AB254666)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SG2NA antibody (AB254666)

Paraffin-embedded human small intestine tissue stained for SG2NA using ab254666 at 1/50 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SG2NA antibody (AB254666)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SG2NA antibody (AB254666)

PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling SG2NA using ab254666 at 4µg/ml (green) in ICC/IF.

Western blot - Anti-SG2NA antibody (AB254666)
  • WB

Supplier Data

Western blot - Anti-SG2NA antibody (AB254666)

Western blot analysis using anti-SG2NA antibody ab254666 (A) shows similar pattern to anti-SG2NA antibody ab254667 (B).

Lane 1:

Western blot - Anti-SG2NA antibody (ab254666)

Lanes 2 - 3:

Western blot - Anti-SG2NA antibody (ab254666) at 0.4 µg/mL

Lane 1:

DNA Ladder

Lane 2:

RT4 (Human urinary bladder cancer cell line) whole cell lysate

Lane 3:

U-251MG whole cell lysate

Predicted band size: 87 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human STRN3 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q13033

style
left-column

組合せ製品

Primary Antibodies

AB253017

Anti-HIP14 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HIP14 antibody (AB253017)

  • 0
  • 0
Primary Antibodies

AB254715

Anti-ZNF503 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

  • 0
  • 0
Primary Antibodies

AB254662

Anti-NPAS3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-NPAS3 antibody (AB254662)

  • 0
  • 1
Primary Antibodies

AB252955

Anti-UROS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UROS antibody (AB252955)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SG2NA also known as Serine/Threonine Phosphatase 2A regulatory subunit B'' is a component of the protein phosphatase 2A (PP2A) complex. SG2NA has a molecular mass of approximately 54 kDa. The protein functions as a regulatory subunit and influences the specificity and activity of the PP2A holoenzyme. SG2NA is expressed in various tissues with notable concentrations in the brain indicating its role in neuronal activities.
Biological function summary

This regulatory protein contributes to several cellular processes through its interaction as part of the PP2A complex. SG2NA plays a significant role in cell cycle regulation controlling cell proliferation and apoptosis. It is involved in dephosphorylating specific substrates that are essential for cellular signal transduction and maintaining protein stability. This control over phosphorylation events impacts cellular responses to external stimuli and internal signals.

Pathways

SG2NA interacts with many signaling cascades notably the PI3K/AKT and MAPK pathways. It regulates the reversal of phosphorylation in these pathways impacting cellular processes such as growth and survival. By modulating the activation states of proteins like AKT and ERK SG2NA indirectly affects complex networks of biological pathways and collaborates with protein partners like PP2A catalytic subunits to maintain cellular homeostasis.

Research has associated SG2NA with neurodegenerative diseases and cancer. Altered function or regulation of SG2NA links to disorders such as Alzheimer’s disease where the protein interacts with tau a related protein aggregating in neurofibrillary tangles. In cancer SG2NA interacts through pathways impacting proteins like p53 reflecting its role in tumor suppression. Understanding the role of SG2NA in these diseases can lead to insights into potential therapeutic targets.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed : 18782753, PubMed : 30622739, PubMed : 33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable).
See full target information STRN3
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 40:1295-1307 PubMed39698827

2024

TRIM22 mechanism promoting KAT2A ubiquitination degradation to regulate ferroptosis in hepatocellular carcinoma cell invasion and metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wang,Xiaoshan Chen,Wei Wei
View all publications
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com