AB687

Anti-Serum Amyloid A 抗体 [115]

Name: Anti-Serum Amyloid A 抗体 [115] (ab687) | Abcam
Brand: Abcam Limited
SKU: AB687
Price: 63000 JPY
Availability: InStock
Rating: 4 (6 reviews)

Anti-Serum Amyloid A antibody [115]

(6 Reviews)

(13 Publications)

Mouse Monoclonal Serum Amyloid A 1 antibody. Carrier free. Suitable for WB, sELISA and reacts with Human, Recombinant full length protein - Human samples. Cited in 13 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SAA1.

別名を表示する

Serum amyloid A-1 protein, SAA, SAA1

2 Images

AbReview23477****

Western blot - Anti-Serum Amyloid A antibody [115] (AB687)

All lanes:

Western blot - Anti-Serum Amyloid A antibody [115] (ab687) at 1/4000 dilution

Lanes 1 - 4:

Acute phase plasma samples at 14 µg

Lane 5:

Recombinant C-SAA at 14 µg

Lane 6:

Recombinant A-SAA at 14 µg

Secondary

All lanes:

Goat anti-mouse IgG-HRP at 1/10000 dilution

true

Exposure time: 5s

Image courtesy of an anonymous Abreview.

Unknown

Western blot - Anti-Serum Amyloid A antibody [115] (AB687)

All lanes:

Western blot - Anti-Serum Amyloid A antibody [115] (ab687) at 0.5 µg/mL

All lanes:

Western blot - Recombinant human Serum Amyloid A (mutated D60N + H71R) protein (<a href='/products/proteins-peptides/recombinant-human-serum-amyloid-a-mutated-d60n-h71r-protein-ab50232'>ab50232</a>) at 0.01 µg

Secondary

All lanes:

Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/5000 dilution

true

Exposure time: 1min

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

115

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

Yes

交差種

Human

アプリケーション

WB, sELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Human SAA1.

P0DJI8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>Use at an assay dependent dilution. This antibody, at a concentration of 0.1-0.5 μg/ml, will allow visualisation of 100 ng/lane of recombinant human SAA.</p>", "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "" }, "Recombinant full length protein - Human": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>sELISA compatible pair - ab18711.</p>" } } }

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製品の詳細

This product was changed from ascites to tissue culture supernatant on 6th March 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

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出荷温度及び保存条件

製品の状態

Liquid

精製に関する特記事項

Affinity purified from tissue culture supernatant.

バッファー組成

Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Serum Amyloid A (SAA) is an important acute-phase protein with a mass of approximately 12 kDa. It plays a role in inflammation and is present in the serum. SAA is an apolipoprotein that associates with high-density lipoprotein (HDL) during inflammatory states. The protein is expressed mainly in the liver and circulating SAA levels greatly increase during inflammatory responses marking it as an important marker for inflammation.

Biological function summary

SAA contributes to the body's immune response to injury by recruiting immune cells and facilitating the removal of cholesterol. As part of the acute-phase response SAA integrates into HDL displacing other apolipoproteins and altering HDL's function. Increased SAA levels can also modulate prostaglandin synthesis and secretion influencing the inflammatory response. The exact role of SAA in pathways beyond these functions continues to be a subject of research.

Pathways

SAA influences lipid metabolism and inflammatory pathways. It plays a significant role within the acute-phase response pathway which modulates the immune system’s reaction to stress such as infection or injury. Another pathway involves cholesterol metabolism where SAA interacts with apolipoproteins AI and AII altering the composition and function of HDL particles.

High levels of SAA associate with amyloidosis and chronic inflammatory diseases. In amyloidosis misfolded SAA proteins deposit as amyloid fibrils in tissues leading to organ dysfunction. In dogs and other species SAA is used as a biomarker to monitor inflammatory diseases. Its connection with C-reactive protein further emphasizes its role in inflammatory processes. Research continues to explore how modulating SAA levels may impact disease progression and treatment.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Major acute phase protein.

See full target information SAA1

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文献 (13)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:4960 PubMed37620307

2023

Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yibing Han,Takeshi Tomita,Masayoshi Kato,Norihiro Ashihara,Yumiko Higuchi,Hisanori Matoba,Weiyi Wang,Hikaru Hayashi,Yuji Itoh,Satoshi Takahashi,Hiroshi Kurita,Jun Nakayama,Nobuo Okumura,Sachie Hiratsuka

International journal of molecular sciences 23: PubMed36430724

2022

Elevated Serum Amyloid A Levels Contribute to Increased Platelet Adhesion in COVID-19 Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Ronen Siman-Tov,Rulla Shalabi,Amir Shlomai,Elad Goldberg,Wesam Essa,Eden Shusterman,Jacob N Ablin,Michal Caspi,Rina Rosin-Arbesfeld,Ella H Sklan

Protein science : a publication of the Protein Society 31:e4485 PubMed36309973

2022

Signal peptide stabilizes folding and inhibits misfolding of serum amyloid A.

Applications

Unspecified application

Species

Unspecified reactive species

Jin-Lin Wu,Yun-Ru Chen

Scientific reports 12:5799 PubMed35388082

2022

Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level.

Applications

Unspecified application

Species

Unspecified reactive species

Jin-Lin Wu,Tung-Hung Su,Pei-Jer Chen,Yun-Ru Chen

Cancer science 113:1140-1153 PubMed35102665

2022

Serum amyloid A 1 induces suppressive neutrophils through the Toll-like receptor 2-mediated signaling pathway to promote progression of breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xingjian Niu,Lei Yin,Xudong Yang,Yue Yang,Yucui Gu,Yutian Sun,Ming Yang,Yiran Wang,Qingyuan Zhang,Hongfei Ji

Veterinary pathology 54:912-921 PubMed28812532

2017

Spontaneous, Experimentally Induced, and Transmissible AA Amyloidosis in Japanese Quail ( Coturnix japonica).

Applications

Unspecified application

Species

Unspecified reactive species

Yumi Nakayama,Junichi Kamiie,Gen Watanabe,Kazuhiko Suzuki,Tomoaki Murakami

Proteomics. Clinical applications 9:695-705 PubMed25656350

2015

Screening protein isoforms predictive for cancer using immunoaffinity capture and fast LC-MS in PRM mode.

Applications

Unspecified application

Species

Unspecified reactive species

Antoine Lesur,Lina Ancheva,Yeoun Jin Kim,Guy Berchem,Jan van Oostrum,Bruno Domon

World journal of gastroenterology 20:17541-51 PubMed25516669

2014

Significance of downregulation of liver fatty acid-binding protein in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Masafumi Inoue,Yoshihisa Takahashi,Takeshi Fujii,Masanobu Kitagawa,Toshio Fukusato

Obesity (Silver Spring, Md.) 21:993-6 PubMed23784902

2013

Serum amyloid A is found on ApoB-containing lipoproteins in obese humans with diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Anisa Jahangiri,Patricia G Wilson,Tianfei Hou,Aparna Brown,Victoria L King,Lisa R Tannock

Proteomics 13:1211-9 PubMed23436750

2013

Comparative proteomic analysis in children with idiopathic short stature (ISS) before and after short-term recombinant human growth hormone (rhGH) therapy.

Applications

Unspecified application

Species

Human

Sun Hee Heo,Jin-Ho Choi,Yoo-Mi Kim,Chang-Woo Jung,Jin Lee,Hye Young Jin,Gu-Hwan Kim,Beom Hee Lee,Choong Ho Shin,Han-Wook Yoo

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-Serum Amyloid A 抗体 [115]

Anti-Serum Amyloid A antibody [115]

Western blot - Anti-Serum Amyloid A antibody [115] (AB687)

Western blot - Anti-Serum Amyloid A antibody [115] (AB687)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (13)

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise