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AB122732

Anti-SEC24D 抗体

Anti-SEC24D antibody

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(1 Publication)

Rabbit Polyclonal SEC24D antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SEC24D aa 800 to C-terminus.

別名を表示する

KIAA0755, SEC24D, Protein transport protein Sec24D, SEC24-related protein D

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24D antibody (AB122732)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24D antibody (AB122732)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling SEC24D with ab122732 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24D antibody (AB122732)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24D antibody (AB122732)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human rectum tissue labelling SEC24D with ab122732 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24D antibody (AB122732)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24D antibody (AB122732)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling SEC24D with ab122732 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24D antibody (AB122732)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24D antibody (AB122732)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling SEC24D with ab122732 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human SEC24D aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O94855

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SEC24D also known as SEC24-related protein D plays an important role in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus by mediating cargo selection for vesicle budding. This protein is part of the COPII coat complex. SEC24D has a molecular mass of approximately 130 kDa. It is widely expressed in most tissues with higher expression levels observed in the liver and testes. Its function in vesicular trafficking makes it essential for maintaining cellular protein transport.
Biological function summary

The protein is involved in the packaging of cargo into COPII vesicles. It operates within the COPII complex which includes proteins like SEC23 SEC13 SEC31 and SAR1. SEC24D functions by recognizing and binding specific cargo sorting signals ensuring proteins reach their correct destination. This process is fundamental in maintaining proper cellular organization and function by facilitating efficient secretory pathways.

Pathways

The SEC24D protein is important in the secretory pathway one of two key pathways for protein transport. It collaborates with the COPII machinery linking endoplasmic reticulum export to various cellular functions. SEC24D works closely with SEC23 in forming budding vesicles which eventually fuse with the Golgi apparatus. The COPII pathway is tightly connected with the ER stress response pathway ensuring cellular adaptation to changes in protein-folding demands.

SEC24D mutations have been linked to congenital disorders of glycosylation and skeletal abnormalities such as osteogenesis imperfecta. SEC24D interacts with other components of the COPII complex like SEC23 which also play a role in these conditions. Understanding the function of SEC24D can provide insights into therapeutic strategies aimed at correcting dysregulated protein trafficking pathways associated with such disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed : 20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed : 18843296).
See full target information SEC24D
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Annals of neurology 89:402-407 PubMed33085104

2020

Progressive Myoclonus Epilepsy Caused by a Homozygous Splicing Variant of SLC7A6OS.

Applications

Unspecified application

Species

Unspecified reactive species

Laure Mazzola,Karen L Oliver,Audrey Labalme,Betül Baykan,Mikko Muona,Tarja H Joensuu,Carolina Courage,Nicolas Chatron,Giuseppe Borsani,Eudeline Alix,Francis Ramond,Renaud Touraine,Melanie Bahlo,Nerses Bebek,Samuel F Berkovic,Anna-Elina Lehesjoki,Gaetan Lesca
View all publications
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