AB228891

Anti-SDCCAG8 抗体

Anti-SDCCAG8 antibody

JP Deleterious:医薬用外劇物

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(1 Publication)

Rabbit Polyclonal SDCCAG8 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SDCCAG8.

別名を表示する

CCCAP, NPHP10, HSPC085, SDCCAG8, Serologically defined colon cancer antigen 8, Antigen NY-CO-8, Centrosomal colon cancer autoantigen protein, hCCCAP

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-SDCCAG8 antibody (AB228891)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SDCCAG8 antibody (AB228891)

A549 (human lung carcinoma cell line) cells stained for SDCCAG8 (green) using ab228891 at 1/200 dilution in ICC/IF. Cells were fixed in ice-cold methanol for 5 minutes. Alpha Tubulin, a cytoskeleton marker (red).

Nuclear counterstain : Hoechst 33342 (blue).

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human SDCCAG8. The exact immunogen used to generate this antibody is proprietary information.

Q86SQ7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SDCCAG8 also known as Serologically Defined Colon Cancer Antigen 8 is a protein weighing approximately 92 kDa. This protein localizes primarily to centrosomes and cilia within the cell. SDCCAG8 gets expressed in many tissues with notable expression in the ciliated cells of the respiratory tract. The protein plays roles in centrosomal organization and the regulation of cilia formation.

Biological function summary

This protein has key roles in cell division and ciliogenesis due to its interaction with other proteins involved in these processes. SDCCAG8 is part of a protein complex that is important for stabilizing centrosomes and promoting proper ciliogenesis. It interacts with centriolar proteins affecting cellular structure and function. Through these interactions SDCCAG8 supports cell cycle progression and normal cellular signaling.

Pathways

SDCCAG8 participates in the centrosome-cilium interface impacting cell division and signaling pathways such as Wnt and Hedgehog. SDCCAG8 collaborates with proteins like OFD1 and CEP290 which contribute to the integrity of these pathways. These associations ensure accurate cellular signaling and distribution of cellular components during mitosis.

SDCCAG8 mutations have been linked to disorders such as Bardet-Biedl syndrome and related ciliopathies. These diseases often involve symptoms like retinal degeneration and polydactyly. The protein's association with others like BBS4 and BBS1 highlights its involvement in the pathological mechanisms of these conditions by affecting the structure and signaling capacity of cilia.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

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ターゲットの情報

Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed : 27224062).

See full target information SDCCAG8

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cardiovascular medicine 9:1062695 PubMed36568562

2022

Large-conductance Ca-activated K channel β1-subunit maintains the contractile phenotype of vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Meili Wang,Shuanglei Li,Hongshan Liu,Mingyuan Liu,Jin Zhang,Yang Wu,Cangsong Xiao,Haixia Huang

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SDCCAG8 抗体

Anti-SDCCAG8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SDCCAG8 antibody (AB228891)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise