AB15093

Anti-SCP3 抗体

Name: Anti-SCP3 抗体 (ab15093) | Abcam
Brand: Abcam Limited
SKU: AB15093
Price: 72000 JPY
Availability: InStock
Rating: 5 (10 reviews)

Anti-SCP3 antibody

(10 Reviews)

(273 Publications)

Anti-SCP3 antibody (ab15093) is a rabbit polyclonal antibody detecting SCP3 in ICC/IF. Suitable for Human, Mouse.

- Over 210 publications
- Trusted since 2004

別名を表示する

SCP3, SYCP3, Synaptonemal complex protein 3, SCP-3

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)

SCP3 labeled in mouse pachytene preparation (red), using ab15093. CDK2 staining, near teleomeres, is also present (green).

ICC/IF

PubMed

Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)

ab15093 staining SCP3 in pig spermatocytes by Immunocytochemistry/ Immunofluorescence. Cells were fixed with formaldehyde, permeabilized with Triton x100 and blocking with 0.15% BSA was performed for 30 minutes at 25⁰C. Samples were incubated with primary antibody (1/100 : in PBT : PBS + 0.15% BSA+0.1% Tween 20) for 12 hours at 25°C. An Alexa Fluor^®594-conjugated donkey polyclonal to rabbit IgG was used at dilution at 1/100 as secondary antibody.

This image is a courtesy of Anonymous Abreview

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Human

アプリケーション

ICC/IF

applications

免疫原

Synthetic Peptide within Human SYCP3. The exact immunogen used to generate this antibody is proprietary information.

Q8IZU3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "1/400", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "1/400", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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製品の詳細

What is this antibody validated in?
Anti-SCP3 antibody (ab15093) is a rabbit polyclonal antibody and is validated for use in Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples.

Trusted by the scientific community
Anti-SCP3 (ab15093) was first used in a scientific publication in 2004 and has been cited over 210 times in peer-reviewed journals.

Reviewed by scientists
Anti-SCP3 (ab15093) has over 5 independent reviews from customers.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

Do Not Freeze

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The SCP3 protein also known as Synaptonemal complex protein 3 and COR1 plays an important role in cell division. It is a component of the synaptonemal complex which is essential during meiosis for chromosome pairing and recombination. SCP3 has a molecular mass of approximately 30 kDa. Researchers observe its expression in germline cells where it facilitates the accurate segregation of homologous chromosomes during the prophase I stage of meiosis.

Biological function summary

SCP3 serves an important function in organizing the scaffold of the synaptonemal complex a highly organized proteinaceous framework. This structure helps in stabilizing the pairing of homologous chromosomes and promoting synapsis. SCP3 does not work alone; it operates as part of a larger complex with other synaptonemal complex components including SCP1 and SCP2. This coordination ensures the successful exchange of genetic material between chromosomes enhancing genetic diversity in gametes.

Pathways

SCP3 integrates into the meiotic recombination process essential for gametogenesis. It aligns with the DNA repair pathway significantly impacting homologous recombination. Proteins like RAD51 and DMC1 are part of these pathways interacting indirectly with SCP3 to facilitate recombination repair processes. SCP3's role helps maintain genome integrity by ensuring faithful chromosome segregation which is critical in producing viable gametes.

SCP3 implicates reproductive issues and genetic schizophrenia predispositions. Abnormal or disrupted function of SCP3 often leads to infertility due to failed meiosis impacting gamete viability. This malfunction may associate with proteins like SPO11 which initiates meiotic recombination. Alterations in SCP3's function or expression have been studied for their potential connections to schizophrenia suggesting a role in neurological development related to errors during meiosis.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed : 14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

See full target information SYCP3

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文献 (273)

Recent publications for all applications. Explore the full list and refine your search

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 33:20 PubMed40958016

2025

CENP-A is diluted during bovine spermatogenesis and is maintained at internally positioned centromere clusters in mature bull sperm.

Applications

Unspecified application

Species

Unspecified reactive species

Miriama Štiavnická,Anna Ní Nualláin,Caitríona M Collins,Elaine M Dunleavy

Zoological research 46:1079-1092 PubMed40923305

2025

Testis-specific protein HSF5 is essential for proper chromatin organization and transcriptional reprogramming to drive pachynema progression.

Applications

Unspecified application

Species

Unspecified reactive species

Chun-Hai Luo,Zhi-Wei Fan,Zi-Qi Yu,Da-Lin Liu,Hao-Ran Xu,Shu-Min Zhou,Xuan-Jing Zhu,Han-Chao Liu,Li-Fu Shao,Zhe-An Li,Chong Xie,Jun-Feng Zhan,Fei Sun

PLoS genetics 21:e1011772 PubMed40758762

2025

Recombination plasticity in response to temperature variation in reptiles.

Applications

Unspecified application

Species

Unspecified reactive species

Laura González-Rodelas,Cristina Marín-García,Clara Romero,Gala Pujol,Laia Marín-Gual,Lukáš Kratochvíl,Aurora Ruiz-Herrera

Heredity : PubMed40745398

2025

Germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes.

Applications

Unspecified application

Species

Unspecified reactive species

Jakub Rídl,Dmitrij Dedukh,Zuzana Halenková,Stephen A Schlebusch,Vladimír Beneš,Mireia Osuna Lopez,Tomasz S Osiejuk,Francisco J Ruiz-Ruano,Alexander Suh,Tomáš Albrecht,Jiří Reif,Radka Reifová

Nature communications 16:6803 PubMed40701999

2025

The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Michael T Bocker,Grigorios Fanourgakis,Kristie Wetzel,Pavel A Komarov,Hélène Royo,Alexia Rohmer,Sunwoo Chun,Ching-Yeu Liang,Hubertus Kohler,Taiping Chen,Xiaohong Mao,Mark A Labow,Reginald A Valdez,Michael B Stadler,Dirk G de Rooij,Paola Capodieci,John Tallarico,Antoine H F M Peters,Thomas B Nicholson

iScience 28:112878 PubMed40686610

2025

UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaochen Yu,Jie Cen,Yaxuan Zhang,Tongtong Li,Mingyu Zhang,Fei Gao,Hongbin Liu,Yongzhi Cao

Biology of reproduction 113:387-396 PubMed40244056

2025

Tendency towards clonality: deviations of meiosis in parthenogenetic Caucasian rock lizards†.

Applications

Unspecified application

Species

Unspecified reactive species

Victor Spangenberg,Marine Arakelyan,Sergey A Simanovsky,Yana Dombrovskaya,Emma R Khachatrian,Oxana Kolomiets

Frontiers in cell and developmental biology 13:1562403 PubMed40181825

2025

Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Laia Marín-Gual,Carolyn J Hogg,J King Chang,Andrew J Pask,Marilyn B Renfree,Paul D Waters,Aurora Ruiz-Herrera

Nature communications 16:2605 PubMed40097464

2025

The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation.

Applications

Unspecified application

Species

Unspecified reactive species

Li Zhang,Jianshu Wang,Zhidong Tang,Zhen Lin,Ruibao Su,Naijing Hu,Yao Tang,Gaoxiang Ge,Jing Fan,Ming-Han Tong,Yuanchao Xue,Yu Zhou,Hong Cheng

Cell research 35:345-361 PubMed40033033

2025

SETD1B-mediated broad H3K4me3 controls proper temporal patterns of gene expression critical for spermatid development.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Lin,Bowen Rong,Ruitu Lyu,Yuxuan Zheng,Yao Chen,Junyi Yan,Meixia Wu,Xiaogang Gao,Fuchou Tang,Fei Lan,Ming-Han Tong

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-SCP3 抗体

Anti-SCP3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)

Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (273)

代替製品

Primary Antibodies

Primary Antibodies

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Primary Antibodies

組合せ製品

Primary Antibodies

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Secondary Antibodies

Primary Antibodies

Abcam product promise