JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB65160

Anti-SCN11A 抗体

Anti-SCN11A antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal SCNBA antibody. Suitable for WB, IHC-P, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SCN11A.

別名を表示する

SCN12A, SNS2, SCN11A, Sodium channel protein type 11 subunit alpha, Peripheral nerve sodium channel 5, Sensory neuron sodium channel 2, Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9, hNaN, PN5

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IHC-P, IHC-Fr, ICC/IF

applications

免疫原

Synthetic Peptide within Human SCN11A. The exact immunogen used to generate this antibody is proprietary information.

Q9UI33

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
style
left-column
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製度
Whole antiserum
バッファー組成
Constituents: Whole serum
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SCN11A also known as Nav1.9 is a voltage-gated sodium channel expressed in peripheral sensory neurons particularly in the dorsal root ganglion and trigeminal ganglion. The protein has an approximate mass of 207 kDa. SCN11A plays an important role in generating and propagating action potentials by allowing sodium ions to enter the cell. This ion influx is important for neuronal excitability and pain signal transmission. Expression of SCN11A is known to be increased in response to certain inflammatory processes and may contribute to pain perception.
Biological function summary

SCN11A contributes to the modulation of neuronal excitability and pain pathways. The channel participates in adjusting the resting membrane potential and firing threshold of neurons. It is hypothesized to function independently rather than as part of a larger protein complex. SCN11A influences the intensity and duration of pain signals affecting the perception of both acute and chronic pain. Its regulation is essential for proper sensory neuron functioning.

Pathways

SCN11A is involved in the nociceptive pain pathway which is responsible for the sensation of pain due to tissue injury. It interacts with other sodium channels such as Nav1.8 to fine-tune pain signaling under various physiological and pathological conditions. Additionally SCN11A is linked to the inflammatory response pathway where its expression can be modulated by pro-inflammatory cytokines. This interaction underlines the channel’s role in mediating neuropathic and inflammatory pain.

SCN11A is associated with neuropathic pain and familial episodic pain syndrome. Mutations in SCN11A can lead to altered channel function resulting in enhanced pain sensitivity or spontaneous pain episodes. The channel's dysfunction is also observed in conditions involving Nav1.7 another sodium channel implicated in pain disorders. Understanding the role of SCN11A in these conditions can provide insights into therapeutic targets for pain management and relief.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed : 10580103, PubMed : 12384689, PubMed : 24036948, PubMed : 24776970, PubMed : 25791876, PubMed : 26645915). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed : 24036948, PubMed : 24776970, PubMed : 25791876, PubMed : 26645915). Also involved in rapid BDNF-evoked neuronal depolarization (PubMed : 12384689).
See full target information SCN11A
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Reproductive biology and endocrinology : RB&E 7:71 PubMed19607678

2009

Molecular and functional characterization of voltage-gated sodium channels in human sperm.

Applications

ICC/IF

Species

Human

Francisco M Pinto,Cristina G Ravina,Manuel Fernández-Sánchez,Manuel Gallardo-Castro,Antonio Cejudo-Román,Luz Candenas
View all publications
style
left-column
style
left-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
style
left-column
style
right-column

関連製品

Select an associated product type
Alternative Product
Primary Antibodies

AB198859

Anti-SCN11A antibody

primary-antibodies

scn11a-antibody-ab198859

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com