JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB214190

Anti-S100 Calcium Binding Protein A13/S100A13 抗体

Anti-S100 Calcium Binding Protein A13/S100A13 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal S100 Calcium Binding Protein A13/S100A13 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Protein S100-A13 aa 50 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

Protein S100-A13, S100 calcium-binding protein A13, S100A13

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 Calcium Binding Protein A13/S100A13 antibody (AB214190)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 Calcium Binding Protein A13/S100A13 antibody (AB214190)

Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human gastric carcinoma tissue labeling S100 Calcium Binding Protein A13/S100A13 with ab214190 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 Calcium Binding Protein A13/S100A13 antibody (AB214190)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 Calcium Binding Protein A13/S100A13 antibody (AB214190)

Immunohistochemical analysis of Formalin-fixed, paraffin-embedded mouse heart tissue labeling S100 Calcium Binding Protein A13/S100A13 with ab214190 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human Protein S100-A13 aa 50 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q99584

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

S100 Calcium Binding Protein A13 also known as S100A13 is a member of the S100 protein family and displays calcium-binding abilities usually binding two calcium ions. This small protein has a molecular mass of approximately 11 kDa. S100A13 is expressed in a variety of tissues including the heart brain and skeletal muscle. Its expression can be altered in different cellular conditions suggesting an adaptive role in diverse physiological contexts.
Biological function summary

S100A13 influences several cellular processes related to growth and differentiation. This protein facilitates secretion of fibroblast growth factor 1 (FGF1) and interleukin-1 alpha (IL-1α) through a non-classical pathway. S100A13 does not function alone; it engages in complexes with other proteins to execute its roles. It often works together with S100A6 and calcyclin-binding protein in these secretory pathways.

Pathways

S100A13 participates in the regulation of angiogenesis and inflammation. It is involved in the FGF signal transduction pathway by affecting the externalization of FGF1 an important player in angiogenesis. Additionally S100A13 contributes to inflammation-related processes. Its activity is linked to proteins such as p53 and FGF1 integrating it into wider cellular systems.

S100A13 is implicated in cancer and chronic inflammatory conditions. Overexpression of S100A13 has links to tumor progression and aggressiveness suggesting a role in cancer. In chronic inflammation S100A13 associates with increased levels of inflammatory cytokines. It connects to proteins like FGF1 and IL-1α in these contexts linking it with pathophysiological mechanisms that underlie these conditions.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).
See full target information Protein S100-A13
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of biochemical and molecular toxicology 38:e70001 PubMed39425457

2024

HIF1A/PCDH7 axis mediates fatty acid synthesis and metabolism to inhibit lung adenocarcinoma anoikis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Yang,Qingfeng Zhang,Liyang Wei,Kui Liu
View all publications
style
left-column
style
left-column
style
right-column

代替製品

Primary Antibodies

AB109252

Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510] (AB109252)

  • 0
  • 0
Primary Antibodies

AB239962

Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510] - BSA and Azide free (AB239962)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB216329

Anti-RAGE antibody [EPR21171]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-RAGE antibody [EPR21171] (AB216329)

  • 4
  • 1
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Primary Antibodies

AB109012

Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker

KO Validated|RabMAb|Recombinant|Lab Essentials

Western blot - Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker (AB109012)

  • 5
  • 15

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com