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リコンビナントRabMAb

Anti-RST 抗体 [EPR12312(2)] (ab181237)

Submit a review Submit a question References (1)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RST antibody [EPR12312(2)] (ab181237)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RST antibody [EPR12312(2)] (ab181237)
  • Anti-RST antibody [EPR12312(2)] (ab181237)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR12312(2)] to RST
  • Suitable for: IHC-P
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-RST antibody [EPR12312(2)]
    RST 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR12312(2)] to RST

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: IHC-Pmore details

  • 種交差性

    交差種: Human

  • 免疫原

    Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ･コントロール

    • Human kidney and renal clear cell carcinoma tissues.

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

製品の特性

  • 製品の状態

    Liquid

  • 保存方法

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • バッファー

    Preservative: 0.01% Sodium azide
    Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
  • Concentration information loading...

  • 精製度

    Protein A purified

  • ポリ/モノ

    モノクローナル

  • クローン名

    EPR12312(2)

  • アイソタイプ

    IgG

  • 研究分野

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab181237の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
IHC-P
1/100. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
特記事項
IHC-P
1/100. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

ターゲット情報

  • 機能

    Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.

  • 組織特異性

    Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.

  • 関連疾患

    Defects in SLC22A12 are a cause of renal hypouricemia (RH) [MIM:220150]. Patients have low serum urate levels, due to defects in renal urate re-absorption and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure (ARF), chronic renal dysfunction and uric acid urolithiasis.

  • 配列類似性

    Belongs to the major facilitator superfamily. Organic cation transporter family.

  • 細胞内局在

    Cell membrane. Detected in the luminal membrane of the epithelium of renal proximal tubules.
  • Information by UniProt

  • 参照データベース

    • 別名

      • Organic anion transporter 4-like protein antibody
      • Renal-specific transporter antibody
      • RST antibody
      • S22AC_HUMAN antibody
      • Slc22a12 antibody
      • Solute carrier family 22 member 12 antibody
      • Urate anion exchanger 1 antibody
      see all

    画像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RST antibody [EPR12312(2)] (ab181237)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RST antibody [EPR12312(2)] (ab181237)

      Immunohistochemical analysis of paraffin-embedded Human renal clear cell carcinoma tissue labeling RST with ab181237 at 1/100 dilution. A prediluted HRP Polymer for Rabbit IgG was used as secondary. Counterstain: Hematoxylin.

      Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RST antibody [EPR12312(2)] (ab181237)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RST antibody [EPR12312(2)] (ab181237)

      Immunohistochemical analysis of paraffin-embedded Human kidney tissue labeling RST using ab181237 at 1/100 dilution. A prediluted HRP Polymer for Rabbit IgG was used as secondary. Counterstain: Hematoxylin.

      Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.

    • Anti-RST antibody [EPR12312(2)] (ab181237)
      Anti-RST antibody [EPR12312(2)] (ab181237)

    参考文献 (1)

    ab181237 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab181237 は 1 報の論文で使用されています。

    • Tang DH  et al. Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model. Pharm Biol 59:175-182 (2021). PubMed: 33715593

    レビューと Q&A

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