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AB22678

Anti-Rpt1 抗体

Anti-Rpt1 antibody

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Rabbit Polyclonal MSS1 antibody. Suitable for WB and reacts with Purified native protein - Yeast, Schizosaccharomyces pombe, Saccharomyces cerevisiae samples. Immunogen corresponding to Recombinant Fragment Protein within Saccharomyces cerevisiae S288C RPT1 aa 1-100.

別名を表示する

CIM5, YTA3, YKL145W, RPT1, 26S proteasome regulatory subunit 7 homolog, Protein CIM5, Tat-binding homolog 3

1 Images
Western blot - Anti-Rpt1 antibody (AB22678)
  • WB

Unknown

Western blot - Anti-Rpt1 antibody (AB22678)

All lanes:

Western blot - Anti-Rpt1 antibody (ab22678) at 1/25000 dilution

All lanes:

Purified yeast 26S proteasome preparation

Predicted band size: 52 kDa

true

Exposure time: 1min

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Saccharomyces cerevisiae, Schizosaccharomyces pombe

アプリケーション

WB

applications

免疫原

Recombinant Fragment Protein within Saccharomyces cerevisiae S288C RPT1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P33299

特異性

At optimal dilution there is no cross-reactivity with other members of the YTA family.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Purified native protein - Yeast": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>" }, "Saccharomyces cerevisiae": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>" }, "Schizosaccharomyces pombe": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>" } } }
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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製度
Whole antiserum
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Rpt1 also known as PSMC2 or 19S proteasome regulatory subunit 2 is a protein involved in the ATPase activity within the 19S regulatory particle of the proteasome. This protein has a molecular weight of approximately 46 kDa and plays an important role in protein degradation. Rpt1 is expressed ubiquitously in various tissues reflecting its importance in cellular functions. The protein's structure includes an ATPase domain which is necessary for energy-dependent unfolding of substrates during proteolysis.
Biological function summary

This protein plays an important role in the function of the ubiquitin-proteasome system (UPS) a complex mechanism responsible for targeted protein degradation. Rpt1 is a component of the 26S proteasome specifically part of the 19S regulatory complex and it assists in the recognition and unfolding of ubiquitinated proteins before they are translocated to the 20S core particle for degradation. The protein's role in UPS is essential for maintaining cellular protein homeostasis by controlling protein levels and quality.

Pathways

The protein is integral to the ubiquitin-proteasome pathway which is essential for various cellular processes like cell cycle control signal transduction and stress response. Within this pathway Rpt1 works closely with other proteasome subunits and associated proteins such as ubiquitin and Rpn1. The protein's activity ensures the timely degradation of regulatory proteins and misfolded proteins allowing for regulation of protein quality and turnover within the cell.

Rpt1 has been implicated in neurodegenerative diseases such as Alzheimer's and certain types of cancers. The dysregulation of proteasome function involving Rpt1 may lead to the accumulation of protein aggregates associated with neuronal degeneration. In cancer alterations in proteasome activity mediated by Rpt1 and related proteins like Rpt2 can affect cell cycle progression and apoptosis evasion contributing to tumorigenesis. Understanding these connections provides insight into potential therapeutic targets within these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
See full target information RPT1
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Abcam product promise

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