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AB10373

Anti-RPRD2 抗体

Anti-RPRD2 antibody

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Goat Polyclonal RPRD2 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human RPRD2.

別名を表示する

KIAA0460, HSPC099, RPRD2, Regulation of nuclear pre-mRNA domain-containing protein 2

1 Images
Western blot - Anti-RPRD2 antibody (AB10373)
  • WB

Unknown

Western blot - Anti-RPRD2 antibody (AB10373)

ab10373 detection of human RPRD2 by Western blot. Samples : Whole cell lysate (WCL; amounts indicated) from HeLa cells. Antibody : ab10373 used at 1 μg/ml. Detection : Chemiluminescence with 3 minute exposure.

ab10373 detection of human RPRD2 by Western blot. Samples : Whole cell lysate (WCL; amounts indicated) from HeLa cells. Antibody : ab10373 used at 1 μg/ml. Detection : Chemiluminescence with 3 minute exposure.

All lanes:

Western blot - Anti-RPRD2 antibody (ab10373)

Predicted band size: 156 kDa

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Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human RPRD2. The exact immunogen used to generate this antibody is proprietary information.

Q5VT52

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Reactivity data

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
Preservative: 0.1% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

RPRD2 also known as Regulation of Nuclear Pre-mRNA Domain-Containing Protein 2 is involved in transcription regulation. It has a molecular weight of approximately 70 kDa and is expressed in various tissues with higher levels found in the liver and kidney. Mechanically RPRD2 interacts with the carboxyl-terminal domain of RNA polymerase II acting as a transcriptional regulator by facilitating the dephosphorylation process. This interaction influences the transcription cycle highlighting its role in gene expression regulation.
Biological function summary

The regulatory activities of RPRD2 impact cellular processes through its part in multiple protein complexes particularly those focusing on transcription and RNA processing. RPRD2 collaborates with other proteins such as RPRD1A and RPRD1B to form a complex involved in mediating interactions with transcription factors and phosphatases. This complex functions in a coordinated manner to regulate the transcription machinery and contribute to RNA polymerase II activity modulation which in turn affects gene expression at a broader level.

Pathways

RPRD2 participates in several critical pathways including the RNA polymerase II transcription pathway and the mRNA maturation pathway. RPRD2's connection with the phosphatase complex places it in a network of interactions vital to maintaining transcriptional fidelity. Additionally RPRD2 is related to pathways involving proteins such as CDK9 which plays a role in controlling pause release at transcription start sites. These interactions position RPRD2 as an essential mediator within transcriptional networks.

RPRD2 has connections to cancer and neurodegenerative disorders. Its role in transcription regulation links it to tumor development with dysregulation potentially contributing to oncogenesis. Additionally the interaction with proteins like RNA polymerase II associates RPRD2 with neurodegenerative diseases where transcriptional dysregulation often plays a significant role. These connections highlight RPRD2 as a significant target for further research in understanding complex diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information RPRD2
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