AB215724

Anti-RPL21 抗体 - N-terminal

Name: Anti-RPL21 抗体 - N-terminal (ab215724) | Abcam
Brand: Abcam Limited
SKU: AB215724
Price: 73000 JPY
Availability: InStock

Anti-RPL21 antibody - N-terminal

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(2 Publications)

Rabbit Polyclonal RPL21 antibody. N-terminal. Suitable for WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RPL21 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

Large ribosomal subunit protein eL21, 60S ribosomal protein L21, RPL21

1 Images

Supplier Data

Western blot - Anti-RPL21 antibody - N-terminal (AB215724)

All lanes:

Western blot - Anti-RPL21 antibody - N-terminal (ab215724) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Lane 4:

TCMK-1 whole cell lysate at 50 µg

Lane 5:

NIH3T3 whole cell lysate at 50 µg

Predicted band size: 19 kDa

true

Exposure time: 10s

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Human

アプリケーション

applications

免疫原

Synthetic Peptide within Human RPL21 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P46778

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Goat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The RPL21 protein also known as 60S ribosomal protein L21 forms part of the ribosomal 60S subunit. This protein weighs approximately 18 kDa. It expresses in various tissues with significant expression in rapidly dividing cells where ribosome production is higher. RPL21 is involved in protein synthesis by contributing to the assembly of ribosomes facilitating the translation of messenger RNA into proteins.

Biological function summary

RPL21 has a significant role in ribosome biogenesis and function. It is a component of the large ribosomal subunit complex which consists of numerous proteins and RNA molecules. This complex translocates along mRNA strands to facilitate the synthesis of polypeptide chains. RPL21's presence in the ribosome is essential for maintaining the structural integrity needed for efficient translation processes.

Pathways

RPL21 acts within the mRNA translation pathway and is important in the ribosome assembly pathway. It interacts directly with other ribosomal proteins such as RPL5 and RPL11 aiding the coordination and assembly of the 60S ribosomal subunit. The ribosome assembly pathway is fundamental in cell growth and division linking RPL21 with regulatory pathways that control protein synthesis rates.

Mutations or dysregulation of RPL21 associate with diamond-blackfan anemia and certain cancers. In diamond-blackfan anemia defective ribosomal proteins like RPL21 lead to impaired ribosome assembly resulting in decreased erythrocyte production. In cancer altered expression of RPL21 may connect with oncogenic pathways where it interacts with proto-oncogenes or tumor suppressors that drive tumorigenesis.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Component of the large ribosomal subunit (PubMed : 12962325, PubMed : 23636399, PubMed : 25901680, PubMed : 25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 12962325, PubMed : 23636399, PubMed : 25901680, PubMed : 25957688).

See full target information RPL21

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular cell 83:1075-1092.e9 PubMed36868228

2023

DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network.

Applications

Unspecified application

Species

Unspecified reactive species

Massimo Carraro,Ivo A Hendriks,Colin M Hammond,Victor Solis-Mezarino,Moritz Völker-Albert,Jonas D Elsborg,Melanie B Weisser,Christos Spanos,Guillermo Montoya,Juri Rappsilber,Axel Imhof,Michael L Nielsen,Anja Groth

Cell reports 41:111571 PubMed36323262

2022

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine M Hannan,Priscilla Soo,Mei S Wong,Justine K Lee,Nadine Hein,Perlita Poh,Kira D Wysoke,Tobias D Williams,Christian Montellese,Lorey K Smith,Sheren J Al-Obaidi,Lorena Núñez-Villacís,Megan Pavy,Jin-Shu He,Kate M Parsons,Karagh E Loring,Tess Morrison,Jeannine Diesch,Gaetan Burgio,Rita Ferreira,Zhi-Ping Feng,Cathryn M Gould,Piyush B Madhamshettiwar,Johan Flygare,Thomas J Gonda,Kaylene J Simpson,Ulrike Kutay,Richard B Pearson,Christoph Engel,Nicholas J Watkins,Ross D Hannan,Amee J George

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-RPL21 抗体 - N-terminal

Anti-RPL21 antibody - N-terminal

Western blot - Anti-RPL21 antibody - N-terminal (AB215724)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Abcam product promise