AB64838

Anti-RIN3 抗体

Name: Anti-RIN3 抗体 (ab64838) | Abcam
Brand: Abcam Limited
SKU: AB64838
Price: 74000 JPY
Availability: InStock

Anti-RIN3 antibody

Be the first to review this product! Submit a review

(2 Publications)

Rabbit Polyclonal RIN3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

別名を表示する

Ras and Rab interactor 3, Ras interaction/interference protein 3, RIN3

1 Images

Unknown

Western blot - Anti-RIN3 antibody (AB64838)

The amount of positive control loading for the WB is 5-30 ug of total protein. The amount of the peptide for the WB is 5-10 ug.

All lanes:

Western blot - Anti-RIN3 antibody (ab64838) at 1/500 dilution

Lane 1:

HUVEC cell extract

Lane 2:

K562 cell extract

Lane 3:

HUVEC cell extract with Immunising peptide

Predicted band size: 108 kDa

Observed band size: 108 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

style

left-column

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Stable for 12 months at -20°C

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

RIN3 also known as Ras and Rab interactor 3 is a member of the RIN family of proteins. This protein has a mass of approximately 100 kDa. RIN3 functions as a GDP-GTP exchange factor which is important for the regulation of endocytosis and actin cytoskeleton organization. It primarily helps in activating small GTPase proteins particularly RAB5 and RAB31. RIN3 expression is found in various tissues with higher levels noted in bone and immune-related tissues.

Biological function summary

This protein influences several important cellular processes including intracellular trafficking and signal transduction. It does not form large complexes itself but it interacts with other proteins like BIN2 which facilitates endocytic vesicle formation and cellular signaling. By these interactions RIN3 contributes to actin cytoskeleton rearrangement and membrane ruffling impacting the cellular uptake and movement.

Pathways

Significant involvement occurs in the endocytic pathway and actin cytoskeleton regulatory pathway. Within the endocytic pathway RIN3 interacts with RAB5 and other related GTPases such as RAB31 orchestrating early endosome dynamics. In the actin cytoskeleton pathway interactions with BIN2 play a role in actin filament modulation which influences cell shape and motility.

RIN3 has been linked to Paget's Disease of Bone and some forms of immunodeficiency. This protein's dysfunction in these conditions relates to its role in bone resorption and immune cell function. Additionally it interacts with SQSTM1 which is associated with bone metabolism and STK11 which relates to immune function disorders. Understanding these interactions and pathways provides insight into RIN3's involvement in disease mechanisms.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

See full target information RIN3

style

left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Translational neurodegeneration 9:26 PubMed32552912

2020

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ruinan Shen,Xiaobei Zhao,Lu He,Yongbo Ding,Wei Xu,Suzhen Lin,Savannah Fang,Wanlin Yang,Kijung Sung,Brian Spencer,Robert A Rissman,Ming Lei,Jianqing Ding,Chengbiao Wu

Molecular and cellular biology 34:4130-42 PubMed25182532

2014

MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Fu,Sunmi Seok,Sunge Choi,Zhang Huang,Kelly Suino-Powell,H Eric Xu,Byron Kemper,Jongsook Kim Kemper

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RIN3 抗体

Anti-RIN3 antibody

Western blot - Anti-RIN3 antibody (AB64838)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise