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AB110927

Anti-RFX1 抗体

Anti-RFX1 antibody

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(1 Publication)

Rabbit Polyclonal RFX1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RFX1 aa 200-250.

別名を表示する

MHC class II regulatory factor RFX1, Enhancer factor C, Regulatory factor X 1, Transcription factor RFX1, EF-C, RFX, RFX1

1 Images
Immunoprecipitation - Anti-RFX1 antibody (AB110927)
  • IP

Unknown

Immunoprecipitation - Anti-RFX1 antibody (AB110927)

Detection of RFX1 by Western Blot of Immunprecipitate.
anti-RFX1 at 0.4µg/ml staining RFX1 in HeLa whole cell lysate immunoprecipitated using ab110927 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection : Chemiluminescence with exposure time of 10 seconds.

All lanes:

Immunoprecipitation - Anti-RFX1 antibody (ab110927)

Predicted band size: 104 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IP

applications

免疫原

Synthetic Peptide within Human RFX1 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

P22670

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab110927 was affinity purified using an epitope specific to RFX1 immobilized on solid support.
バッファー組成
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Regulatory Factor X 1 (RFX1) also known as EF-C is a transcription factor essential for gene regulation. It has a mass of approximately 98 kDa. This protein is expressed in various tissues including the brain and immune cells influencing cellular functions in different contexts. It functions by binding to specific DNA sequences known as X-boxes located in the promoter regions of target genes. This binding regulates transcription impacting cell growth differentiation and immune response.
Biological function summary

RFX1 participates in a broader network of transcriptional regulation as part of the RFX protein family. It is involved in the regulation of genes necessary for cilia function and immune response. RFX1 often operates in synergy with other transcription factors forming complexes that modulate gene expression. It plays an important role in controlling the expression of genes critical for cell cycle regulation and apoptosis.

Pathways

The transcription factor RFX1 contributes to major biological pathways such as the MHC class II antigen presentation pathway and the cilia development pathway. It interacts with proteins like CIITA influencing immune response through the activation of MHC class II genes. By regulating these pathways RFX1 affects immune surveillance and cellular communication which are pivotal for maintaining cellular integrity and function.

Dysfunction or dysregulation of RFX1 relates to conditions such as cancer and autoimmune diseases. The protein's critical role in gene expression and the immune system highlights its contribution to oncogenic processes and disorders like systemic lupus erythematosus. It may interact with proteins such as STAT3 suggesting pathways through which RFX1 may influence inflammatory responses and tumorigenesis making it a potential target for therapeutic intervention.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.
See full target information RFX1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:698292 PubMed34458260

2021

3D Organoid Culture From Adult Salivary Gland Tissues as an Modeling of Salivary Gland Morphogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Donghyun Kim,Yeo-Jun Yoon,Dojin Choi,Jisun Kim,Jae-Yol Lim
View all publications
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