AB228496

Anti-RFRP 抗体

Name: Anti-RFRP 抗体 (ab228496) | Abcam
Brand: Abcam Limited
SKU: AB228496
Price: 74000 JPY
Availability: InStock

Anti-RFRP antibody

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(2 Publications)

Guinea pig Polyclonal RFRP antibody. Suitable for IHC-Fr and reacts with Sheep samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NPVF aa 100-150 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

C7orf9, RFRP, NPVF, Pro-FMRFamide-related neuropeptide VF

4 Images

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with Prolactin-releasing peptide (PrRP).

IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with Kisspeptin.

IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with NFF peptide.

IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis.

Key facts

宿主種

Guinea pig

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Sheep

アプリケーション

IHC-Fr

applications

免疫原

Synthetic Peptide within Human NPVF aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9HCQ7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Sheep": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/2000", "IHCFr-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Lyophilized

再構成

reconstitute with water at 50µL

精製度

Whole antiserum

バッファー組成

pH: 7 - 7.4

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

RFRP also known as RFamide-related peptide ranges in mass from 1.38 kDa to 2.85 kDa depending on the specific peptide variant. RFRP is expressed in the central nervous system particularly in the hypothalamus and pituitary gland and also found within the testis and ovary tissues. It originates from the VGF peptide precursor and plays a role in modulating various physiological processes.

Biological function summary

The RFamide-related peptide influences reproductive functions such as the regulation of gonadotropin release. It functions as an inhibitory factor on the secretion of gonadotropin-releasing hormone (GnRH) working in tandem with other neuropeptides and factors. RFRP is not a part of a larger complex but interacts closely with related neurohormones to exert its physiological effects.

Pathways

Several neuroendocrine control systems involve the RFamide-related peptide. RFRP plays an important role in the hypothalamic-pituitary-gonadal (HPG) axis where it modulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It interacts with receptor proteins like GPR147 which influences these essential pathways and subsequently affects reproductive system functionality.

The RFamide-related peptide has links to reproductive health issues such as delayed puberty and infertility. Abnormal activities or levels of RFRP can interfere with hormonal balance making it a potential target for addressing these reproductive system disorders. Additionally its regulation of GnRH suggests possible connections to disorders involving altered hormonal cycles including polycystic ovary syndrome (PCOS) where excessive or insufficient RFRP activity can disrupt cyclical hormone release patterns.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Neuropeptide RFRP-1. Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion (PubMed : 11025660, PubMed : 20027225). Induces secretion of prolactin (By similarity).. Neuropeptide NPVF. Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia.. Neuropeptide RFRP-2. Shows no inhibitory activity of forskolin-induced production of cAMP.

See full target information NPVF

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed39122556

2024

Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations.

Applications

Unspecified application

Species

Unspecified reactive species

Dana Sagi,Muhammad Tibi,Inbal Admati,Tali Lerer-Goldshtein,Hannah Hochgerner,Amit Zeisel,Lior Appelbaum

Nutrients 13: PubMed34684588

2021

A Role for Peripheral Anandamide and 2-Arachidonoylglycerol in Short-Term Food Intake and Orexigenic Hypothalamic Responses in a Species with Continuous Nutrient Delivery.

Applications

Unspecified application

Species

Unspecified reactive species

Isabel van Ackern,Angela Kuhla,Björn Kuhla

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RFRP 抗体

Anti-RFRP antibody

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

再構成

精製度

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

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組合せ製品

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Primary Antibodies

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