AB20745

Anti-Respiratory Syncytial Virus 抗体

Name: Anti-Respiratory Syncytial Virus 抗体 (ab20745) | Abcam
Brand: Abcam Limited
SKU: AB20745
Price: 71000 JPY
Availability: InStock

Anti-Respiratory Syncytial Virus antibody

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(44 Publications)

Anti-Respiratory Syncytial Virus antibody (ab20745) is a goat polyclonal antibody detecting Respiratory Syncytial Virus in Western Blot, IHC-P, ICC/IF, ELISA. Suitable for Respiratory syncytial virus.

- Over 40 publications
- Trusted since 2005

別名を表示する

RS virus, RSV

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Respiratory syncytial virus

アプリケーション

WB, IHC-P, Conjugation, ICC/IF, ELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "Conjugation" : {"fullname" : "Conjugation", "shortname":"Conjugation"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Respiratory syncytial virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "Conjugation-species-checked": "guaranteed", "Conjugation-species-dilution-info": "", "Conjugation-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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製品の詳細

What is this antibody validated in?
Anti-Respiratory Syncytial Virus antibody (ab20745) is a goat polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in Respiratory syncytial virus samples.

Trusted by the scientific community
Anti-Respiratory Syncytial Virus (ab20745) was first used in a scientific publication in 2005 and has been cited over 40 times in peer-reviewed journals.

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出荷温度及び保存条件

製品の状態

Liquid

精製度

IgG fraction

精製に関する特記事項

Sodium sulphate precipitation and DEAE chromatography.

バッファー組成

Preservative: 0.1% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Respiratory Syncytial Virus (RSV) is a negative-sense single-stranded RNA virus known to cause respiratory infections. It belongs to the Paramyxoviridae family and is sometimes referred to by its alternate names like Human Orthopneumovirus. RSV is approximately 15 kb in size. It is predominantly expressed in the respiratory tract where it attacks epithelial cells leading to infection. The virus's ability to form a syncytium a large multinucleate cell is one of its mechanical strategies to aid in the spread across the host cells.

Biological function summary

The virus propagates efficiently within the host tissue leading to serious respiratory illness in infants and young children. RSV is not part of a specific complex but it engages host cellular machinery to promote its replication and prevent immune detection. The fusion (F) protein of RSV plays a critical role in mediating membrane fusion facilitating viral entry into the host cells. The involvement of viral proteins in modulating host immune responses is significant for the virus's life cycle.

Pathways

Respiratory infections caused by RSV connect to the host's immune signaling pathways including the toll-like receptor (TLR) pathways and the interferon response pathway. The interaction of RSV proteins with these pathways leads to an increased inflammatory response. Proteins such as the RSV G protein interface with the chemokine receptor pathway which helps in modulation of the immune system to allow viral persistence. These interactions demonstrate the virus's strategies to evade immune surveillance and promote infection.

Respiratory syncytial virus is a major cause of bronchiolitis and pneumonia in infants and young children. The virus's activity in the respiratory tract contributes to severe inflammation and cell damage which can lead to hospitalization. Other proteins like RSV M protein are involved in virus assembly and budding and they passively influence disease progression by impacting viral load and the host's immune response. Understanding these interactions is important for developing therapeutic strategies including anti-RSV monoclonal antibodies like palivizumab (2F7) which target prominent viral components to prevent severe disease outcomes.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information Respiratory Syncytial Virus

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文献 (44)

Recent publications for all applications. Explore the full list and refine your search

Npj viruses 3:2 PubMed40295717

2025

Syrian hamsters (Mesocricetus auratus) as an upper respiratory tract model for respiratory syncytial virus infection.

Applications

Unspecified application

Species

Unspecified reactive species

Sophie M Kolbe,Kate Guilfoyle,Wencke Reineking,Geert van Amerongen,Guido van der Net,Sandra Lockow,Wolfgang Baumgärtner,Martin Ludlow,Albert D M E Osterhaus

The Journal of infection 89:106305 PubMed39389204

2024

Infant-derived human nasal organoids exhibit relatively increased susceptibility, epithelial responses, and cytotoxicity during RSV infection.

Applications

Unspecified application

Species

Unspecified reactive species

Gina M Aloisio,Divya Nagaraj,Ashley M Murray,Emily M Schultz,Trevor McBride,Letisha Aideyan,Erin G Nicholson,David Henke,Laura Ferlic-Stark,Anubama Rajan,Amal Kambal,Hannah L Johnson,Elina Mosa,Fabio Stossi,Sarah E Blutt,Pedro A Piedra,Vasanthi Avadhanula

Vaccines 12: PubMed38932414

2024

Immune Responses and Protection Profiles in Mice Induced by Subunit Vaccine Candidates Based on the Extracellular Domain Antigen of Respiratory Syncytial Virus G Protein Combined with Different Adjuvants.

Applications

Unspecified application

Species

Unspecified reactive species

Ruiwen Han,Tangqi Wang,Xueting Cheng,Jialuo Bing,Jia Li,Yao Deng,Xuchang Shan,Xuejie Zhang,Donghong Wang,Shucai Sun,Wenjie Tan

International journal of molecular sciences 24: PubMed38069117

2023

APOBEC3G Is a p53-Dependent Restriction Factor in Respiratory Syncytial Virus Infection of Human Cells Included in the p53/Immune Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Wesley Gladwell,Oriana Yost,Heather Li,Whitney J Bell,Shih-Heng Chen,James M Ward,Steven R Kleeberger,Michael A Resnick,Daniel Menendez

Nature communications 14:5885 PubMed37735161

2023

Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K during entry.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha Hover,Frank W Charlton,Jan Hellert,Jessica J Swanson,Jamel Mankouri,John N Barr,Juan Fontana

PLoS pathogens 19:e1011597 PubMed37669278

2023

Antagonism between viral infection and innate immunity at the single-cell level.

Applications

Unspecified application

Species

Unspecified reactive species

Frederic Grabowski,Marek Kochańczyk,Zbigniew Korwek,Maciej Czerkies,Wiktor Prus,Tomasz Lipniacki

JCI insight 8: PubMed37159271

2023

Human T cells efficiently control RSV infection.

Applications

Unspecified application

Species

Unspecified reactive species

Chandrav De,Raymond J Pickles,Wenbo Yao,Baolin Liao,Allison Boone,Mingyu Choi,Diana M Battaglia,Frederic B Askin,Jason K Whitmire,Guido Silvestri,J Victor Garcia,Angela Wahl

Cells 12: PubMed37174711

2023

Respiratory Syncytial Virus Matrix Protein Is Sufficient and Necessary to Remodel Host Mitochondria in Infection.

Applications

Unspecified application

Species

Unspecified reactive species

MengJie Hu,Marie A Bogoyevitch,David A Jans

Journal of virology 96:e0134122 PubMed36326278

2022

Respiratory Syncytial Virus Protects Bystander Cells against Influenza A Virus Infection by Triggering Secretion of Type I and Type III Interferons.

Applications

Unspecified application

Species

Unspecified reactive species

Maciej Czerkies,Marek Kochańczyk,Zbigniew Korwek,Wiktor Prus,Tomasz Lipniacki

Nature microbiology 7:1879-1890 PubMed36280786

2022

Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles.

Applications

Unspecified application

Species

Unspecified reactive species

Joanne Haney,Swetha Vijayakrishnan,James Streetley,Kieran Dee,Daniel Max Goldfarb,Mairi Clarke,Margaret Mullin,Stephen D Carter,David Bhella,Pablo R Murcia

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Respiratory Syncytial Virus 抗体

Anti-Respiratory Syncytial Virus antibody

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製度

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (44)

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