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AB31291

Anti-Renalase 抗体

Anti-Renalase antibody

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(9 Publications)

Goat Polyclonal Renalase antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human RNLS aa 200-250.

別名を表示する

C10orf59, RNLS, Renalase, Monoamine oxidase-C, MAO-C

1 Images
Western blot - Anti-Renalase antibody (AB31291)
  • WB

Supplier Data

Western blot - Anti-Renalase antibody (AB31291)

35μg protein in RIPA buffer. Detected by chemiluminescence.

All lanes:

Western blot - Anti-Renalase antibody (ab31291) at 1 µg/mL

Lane 1:

Human heart tissue lysate at 35 µg

Lane 2:

Mouse heart tissue lysate at 35 µg

Lane 3:

Rat heart tissue lysate at 35 µg

Predicted band size: 38 kDa

false

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Rat, Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human RNLS aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

Q5VYX0

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Reactivity data

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
バッファー組成
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Renalase also known as RNLS is a flavoprotein that catalyzes the oxidation of catecholamines such as dopamine and norepinephrine. It has a mass of approximately 37 kDa. The protein is expressed in the kidney heart and other tissues including the liver and brain. Its enzymatic activity helps in regulating blood pressure and cardiac function by metabolizing circulating monoamines.
Biological function summary

Renalase impacts the cardiovascular system through its enzymatic function that reduces systemic catecholamine levels. It has been shown the protein interacts with catecholamines beyond the boundaries of a simple enzymatic reaction. Renalase may form complexes with other enzymes that participate in detoxifying catecholamines. Researchers have studied its effects on catecholamine-related stress responses highlighting a potential modulatory function beyond simple substrate degradation.

Pathways

The metabolism of catecholamines involves Renalase in the regulation of the sympathetic nervous system and its associated pathways. Renalase fits into the catecholamine degradation pathway where it works alongside other enzymes such as monoamine oxidase which also breaks down neurotransmitters. These actions influence the broader systemic pathways associated with cardiovascular health by maintaining a balance in neurotransmitter levels and resultant blood pressure regulation.

Renalase has been associated with hypertension due to its role in catecholamine metabolism. Abnormal Renalase function can contribute to increased circulating catecholamines leading to elevated blood pressure. Additionally studies have suggested a link between Renalase and chronic kidney disease where alterations in Renalase activity may exacerbate kidney dysfunction. The relationship between Renalase and proteins like angiotensin-converting enzyme (ACE) further hints at its potential involvement in blood pressure regulation and renal pathology.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
See full target information RNLS
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文献 (9)

Recent publications for all applications. Explore the full list and refine your search

Kidney international reports 5:362-368 PubMed32154458

2020

Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality.

Applications

Unspecified application

Species

Unspecified reactive species

J Chang,X Guo,V Rao,E S Gromisch,S Chung,H M Kluger,C Cha,F Gorelick,J Testani,R Safirstein,S Crowley,A J Peixoto,G V Desir

International journal of cardiology 279:155-161 PubMed30630613

2019

Elevated renalase levels in patients with acute coronary microvascular dysfunction - A possible biomarker for ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Basmah Safdar,Xiaojia Guo,Caitlin Johnson,Gail D'Onofrio,James Dziura,Albert J Sinusas,Jeffrey Testani,Veena Rao,Gary Desir

Cancer research 76:3884-94 PubMed27197188

2016

Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Lindsay Hollander,Xiaojia Guo,Heino Velazquez,John Chang,Robert Safirstein,Harriet Kluger,Charles Cha,Gary V Desir

Scientific reports 6:22996 PubMed26972355

2016

Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojia Guo,Lindsay Hollander,Douglas MacPherson,Ling Wang,Heino Velazquez,John Chang,Robert Safirstein,Charles Cha,Fred Gorelick,Gary V Desir

PloS one 10:e0139627 PubMed26431044

2015

Serum Renalase Levels Correlate with Disease Activity in Lupus Nephritis.

Applications

Unspecified application

Species

Unspecified reactive species

Chaojun Qi,Ling Wang,Minfang Zhang,Xinghua Shao,Xinbei Chang,Zhuping Fan,Qin Cao,Shan Mou,Qin Wang,Yucheng Yan,Gary Desir,Zhaohui Ni

Journal of cellular and molecular medicine 19:1400-9 PubMed25781495

2015

Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α.

Applications

WB

Species

Unspecified reactive species

Feng Wang,Guangyuan Zhang,Tao Xing,Zeyuan Lu,Junhui Li,Cheng Peng,Guohua Liu,Niansong Wang

Kidney & blood pressure research 39:252-9 PubMed25171187

2014

Epinephrine evokes renalase secretion via α-adrenoceptor/NF-κB pathways in renal proximal tubular epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Wang,Hongyan Cai,Qing Zhao,Tao Xing,Junhui Li,Niansong Wang

Journal of the American Society of Nephrology : JA 24:445-55 PubMed23393318

2013

Renalase protects against ischemic AKI.

Applications

WB

Species

Mouse

H Thomas Lee,Joo Yun Kim,Mihwa Kim,Peili Wang,Lieqi Tang,Sara Baroni,Vivette D D'Agati,Gary V Desir

Protein expression and purification 72:244-53 PubMed20302943

2010

Synthesis of human renalase1 in Escherichia coli and its purification as a FAD-containing holoprotein.

Applications

WB

Species

Human

Vittorio Pandini,Francesco Ciriello,Gabriella Tedeschi,Giuseppe Rossoni,Giuliana Zanetti,Alessandro Aliverti
View all publications
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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Product
Primary Antibodies

AB236560

Anti-Renalase antibody [RNLS/1940]

primary-antibodies

renalase-antibody-rnls-1940-ab236560

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