AB39626

Anti-RELM alpha/Retnla 抗体

Name: Anti-RELM alpha/Retnla 抗体 (ab39626) | Abcam
Brand: Abcam Limited
SKU: AB39626
Price: 83000 JPY
Availability: InStock
Rating: 5 (4 reviews)

Anti-RELM alpha/Retnla antibody

(4 Reviews)

(41 Publications)

Rabbit Polyclonal RELM alpha/Retnla antibody. Suitable for ELISA, WB, IHC-P, IHC-Fr and reacts with Mouse samples. Cited in 41 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Retnla.

別名を表示する

Fizz1, Himf, Pmng1, Retnla, Resistin-like alpha, Cysteine-rich secreted protein A12-gamma, Cysteine-rich secreted protein FIZZ1, Hypoxia-induced mitogenic factor, Parasite-induced macrophage novel gene 1 protein, RELMalpha

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse

アプリケーション

IHC-Fr, ELISA, WB, IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Mouse Retnla.

Q9EP95

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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製品の詳細

Although some customers have been successful in IHC we no longer batch test in this application.

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出荷温度及び保存条件

製品の状態

Lyophilized

再構成

reconstitute with water at 0.2mg/mL

精製方法

Affinity purification Immunogen

バッファー組成

Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

RELM alpha also known as Retnla is a small secreted protein with a molecular mass of approximately 10 kDa. It belongs to the resistin-like molecule family and is mainly expressed in adipose tissues and the lungs. However some expression also occurs in the gastrointestinal tract and immune cells. It plays a role as a signaling molecule and is secreted under various physiological and pathological conditions.

Biological function summary

RELM alpha functions as a modulator of immune responses and inflammation. It has a part in the immune network and participates in the regulation of insulin sensitivity. While it does not form part of a specific complex it interacts with other cytokines and chemokines to modulate the activity of macrophages and other immune cells. This modulation impacts the balance between pro-inflammatory and anti-inflammatory signals in the body.

Pathways

RELM alpha plays roles in the metabolic and immune pathways. It influences the toll-like receptor signaling pathway which involves key proteins like TLR4 which is essential for pathogen recognition and innate immunity. RELM alpha also appears in pathways related to glucose metabolism interacting with other metabolic regulators to affect energy homeostasis and insulin action.

RELM alpha has connections to conditions like obesity and asthma. In obesity levels of RELM alpha may correlate with inflammatory states and insulin resistance interacting with proteins like adiponectin and leptin. In asthma RELM alpha may contribute to airway inflammation working alongside proteins like IL-13 to drive inflammatory responses in the respiratory system. These associations make RELM alpha a significant target for therapeutic investigation in related disorders.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Probable hormone. Plays a role in pulmonary vascular remodeling.

See full target information Retnla

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文献 (41)

Recent publications for all applications. Explore the full list and refine your search

Respiratory research 25:428 PubMed39633343

2024

T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Li,Pingping Liu,Hao Zhu,Huan Yang,Jun Zha,Huiling Yao,Shaoze Zhang,Jin Huang,Guang Li,Gang Jiang,Yongliang Jiang,Aiguo Dai

Frontiers in pharmacology 15:1460692 PubMed39386033

2024

Airspaces-derived exosomes contain disease-relevant protein signatures in a mouse model of cystic fibrosis (CF)-like mucoinflammatory lung disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Mao,Amol Suryawanshi,Sonika Patial,Yogesh Saini

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 73:725-737 PubMed38538755

2024

Bakuchicin alleviates ovalbumin-induced allergic asthma by regulating M2 macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Yeon-Yong Kim,Seungwon Jeong,Seung Woong Lee,Seung-Jae Lee,Mun-Chual Rho,Sang-Hyun Kim,Soyoung Lee

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e23259 PubMed37855749

2023

Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaqi He,Lan Wei,Shengan Tan,Birong Liang,Jing Liu,Lu Lu,Ting Wang,Junyan Wang,Yusheng Huang,Zixin Chen,Huan Li,Lu Zhang,Zheng Zhou,Yanhong Cao,Xiaohan Ye,Zhongqi Yang,Shaoxiang Xian,Lingjun Wang

iScience 26:107496 PubMed37636061

2023

Galectin-3 as TREM2 upstream factor contributes to lung ischemia-reperfusion injury by regulating macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Liu,Lu Zhang,Zhen Liu,Jinyuan Lin,Xiaojing He,Siyi Wu,Yi Qin,Chen Zhao,Youyuan Guo,Fei Lin

Frontiers in pharmacology 14:1145188 PubMed36998616

2023

Artesunate inhibits airway remodeling in asthma the MAPK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyuan Zhang,Jiangtao Lin,Jingyuan Zhang,Ruiheng Zhao,Jingxuan Wan,Ying Nong

American journal of translational research 14:8129-8145 PubMed36505286

2022

MiR-216b targets CPEB4 to suppress colorectal cancer progression through inhibiting IL-10-mediated M2 polarization of tumor-associated macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Zou,Boyu Wu,Chao Lin,Qunhua Ding,Jiangtao Li

Methods and protocols 5: PubMed36136814

2022

In Vitro Screening Method for Characterization of Macrophage Activation Responses.

Applications

Unspecified application

Species

Unspecified reactive species

Brandon W Lewis,Sonika Patial,Yogesh Saini

Cell : PubMed35777355

2022

A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Zhang,Yibin Zhu,Ziwen Liu,Yongmei Peng,Wenyu Peng,Liangqin Tong,Jinglin Wang,Qiyong Liu,Penghua Wang,Gong Cheng

Stem cell research & therapy 13:109 PubMed35313972

2022

Human umbilical cord-derived mesenchymal stem cells alleviate insulin resistance in diet-induced obese mice via an interaction with splenocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Xue,Jieqing Gao,Yulin Gu,Aihong Wang,Songyan Yu,Bing Li,Yaqi Yin,Jie Wang,Wanlu Su,Haixia Zhang,Weizheng Ren,Weijun Gu,Zhaohui Lv,Yiming Mu,Yu Cheng

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RELM alpha/Retnla 抗体

Anti-RELM alpha/Retnla antibody

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

再構成

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (41)

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise