AB231092

Anti-REG1 alpha 抗体

Name: Anti-REG1 alpha 抗体 (ab231092) | Abcam
Brand: Abcam Limited
SKU: AB231092
Price: 72000 JPY
Availability: InStock

Anti-REG1 alpha antibody

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(1 Publication)

Rabbit Polyclonal LITH antibody. Suitable for WB, IHC-P and reacts with Rat, Recombinant full length protein - Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Reg1.

別名を表示する

Reg, Reg1, Lithostathine, Islet cells regeneration factor, Islet of Langerhans regenerating protein, Pancreatic stone protein, Pancreatic thread protein, ICRF, REG, PSP, PTP

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REG1 alpha antibody (AB231092)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REG1 alpha antibody (AB231092)

Formalin-fixed, paraffin-embedded rat intestine tissue stained for REG1 alpha using ab231092 at 20 μg/ml in immunohistochemical analysis, followed by DAB staining.

Supplier Data

Western blot - Anti-REG1 alpha antibody (AB231092)

All lanes:

Western blot - Anti-REG1 alpha antibody (ab231092) at 2 µg/mL

All lanes:

Recombinant rat REG1 alpha protein

Predicted band size: 19 kDa

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Supplier Data

Western blot - Anti-REG1 alpha antibody (AB231092)

All lanes:

Western blot - Anti-REG1 alpha antibody (ab231092) at 2 µg/mL

Lane 1:

Rat pancreas lysate

Lane 2:

Mouse pancreas lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit antibody at 1/1000 dilution

Predicted band size: 19 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Rat

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Rat Reg1.

P10758

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Recombinant full length protein - Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

ab231092 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

バッファー組成

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

REG1 alpha also known as regenerating islet-derived protein 1 alpha or REG1A is a 19 kDa protein. Found primarily in the pancreas this protein also shows expression in gastric and intestinal tissues. REG1 alpha belongs to the C-type lectin superfamily known for their carbohydrate recognition capabilities. The protein involves itself directly in cell growth and proliferation through regenerative patterns essential for cellular homeostasis.

Biological function summary

The REG1 alpha protein stimulates pancreatic beta-cell proliferation influencing insulin production and secretion. It exists as a monomer but may participate in larger complexes during specific cellular responses. Its role expands to the modulation of cellular differentiation and inflammation control within the gastrointestinal tract. By aiding tissue repair REG1 alpha contributes to the maintenance of a healthy epithelial lining.

Pathways

The mitogen-activated protein kinase (MAPK) pathway sees REG1 alpha engaging in the regulation of cell proliferation by interacting with similar proteins involved in this signaling cascade. It also plays a role in the JAK-STAT pathway where it coordinates with the interleukins which are important for signaling that controls immune responses. REG1 alpha’s function in these pathways highlights its role in the regulation of growth and repair mechanisms.

REG1 alpha shows altered expression patterns in diabetes and some forms of cancer such as pancreatic cancer. In diabetes the protein’s involvement with glucose metabolism connects it to insulin regulation issues often interacting with insulin signaling proteins. In pancreatic cancer changes in REG1 alpha levels correlate with cellular growth and tissue regeneration processes that may become dysregulated further involving proteins like KRAS that stimulate cancer cell proliferation.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Might act as an inhibitor of spontaneous calcium carbonate precipitation.

See full target information Reg1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:335 PubMed40089779

2025

F-box protein FBXO21 overexpression inhibits the proliferation and metastasis of clear cell renal cell carcinoma and is closely related to the CREB pathway and tumor immune cell infiltration.

Applications

Unspecified application

Species

Unspecified reactive species

Wuping Yang,Taile Jing,Cunjin Wu,Minghao Lu,Xiaolin Yao,Dan Xia,Ding Peng

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-REG1 alpha 抗体

Anti-REG1 alpha antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REG1 alpha antibody (AB231092)

Western blot - Anti-REG1 alpha antibody (AB231092)

Western blot - Anti-REG1 alpha antibody (AB231092)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Abcam product promise