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リコンビナントRabMAb

Anti-RAIDD 抗体 [EPR1639] (ab76465)

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Western blot - Anti-RAIDD antibody [EPR1639] (ab76465)
  • Anti-RAIDD antibody [EPR1639] (ab76465)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR1639] to RAIDD
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-RAIDD antibody [EPR1639]
    RAIDD 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR1639] to RAIDD

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: WBmore details
    適用なし: IHC-P

  • 種交差性

    交差種: Human
    交差が予測される動物種: Rat

  • 免疫原

    Synthetic peptide within Human RAIDD aa 100-200. The exact sequence is proprietary.

  • ポジティブ･コントロール

    • Raji, HeLa, K562 and MCF7 cell lysates.

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab76465の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB
1/1000 - 1/5000. Predicted molecular weight: 23 kDa.
特記事項
WB
1/1000 - 1/5000. Predicted molecular weight: 23 kDa.
追加情報
Is unsuitable for IHC-P.

ターゲット情報

  • 機能

    Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

  • 組織特異性

    Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

  • 配列類似性

    Contains 1 CARD domain.
    Contains 1 death domain.

  • ドメイン

    Contains a death domain involved in the binding of RIP protein.
    The CARD domain mediates the interaction with caspase-2.
  • Information by UniProt

  • 参照データベース

    • 別名

      • CASP2 and RIPK1 domain containing adaptor with death domain antibody
      • Caspase and RIP adapter with death domain antibody
      • Caspase and RIP adaptor with death domain antibody
      • Cradd antibody
      • CRADD_HUMAN antibody
      • Death adaptor molecule RAIDD antibody
      • Death domain containing protein CRADD antibody
      • Death domain-containing protein CRADD antibody
      • MGC9163 antibody
      • RIP associated ICH1/CED3 homologous protein with death domain antibody
      • RIP associated protein with a death domain antibody
      • RIP-associated protein with a death domain antibody
      see all

    画像

    • Western blot - Anti-RAIDD antibody [EPR1639] (ab76465)
      Western blot - Anti-RAIDD antibody [EPR1639] (ab76465)
      All lanes : Anti-RAIDD antibody [EPR1639] (ab76465) at 1/5000 dilution

      Lane 1 : Raji cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : K562 cell lysate
      Lane 4 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 23 kDa
      Observed band size: 23 kDa

    • Anti-RAIDD antibody [EPR1639] (ab76465)
      Anti-RAIDD antibody [EPR1639] (ab76465)

    参考文献 (2)

    ab76465 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab76465 は 2 報の論文で使用されています。

    • Vigneswara V & Ahmed Z Pigment epithelium-derived factor mediates retinal ganglion cell neuroprotection by suppression of caspase-2. Cell Death Dis 10:102 (2019). PubMed: 30718480
    • Di Donato N  et al. Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. Am J Hum Genet 99:1117-1129 (2016). PubMed: 27773430

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