AB109242

Anti-R Cadherin 抗体 [EPR4836]

Anti-R Cadherin antibody [EPR4836]

RabMAb
Recombinant
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(3 Publications)

Rabbit Recombinant Monoclonal CADH4 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

別名を表示する

Cadherin-4, Retinal cadherin, R-CAD, R-cadherin, CDH4

1 Images

Unknown

Western blot - Anti-R Cadherin antibody [EPR4836] (AB109242)

All lanes:

Western blot - Anti-R Cadherin antibody [EPR4836] (ab109242) at 1/10000 dilution

Lane 1:

HepG2 cell lysate at 10 µg/mL

Lane 2:

Fetal brain lysate at 10 µg/mL

Lane 3:

SH-SY5Y cell lysate at 10 µg/mL

Predicted band size: 100 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR4836

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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製品の詳細

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Stable for 12 months at -20°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

R Cadherin also known as Cadherin-4 or CDH4 is a classical cadherin that plays a role in calcium-dependent cell-cell adhesion. This protein weighs approximately 90 kDa. It expresses in neural tissues particularly within the developing central nervous system as well as in the retina and certain epithelial tissues. R Cadherin is a member of the cadherin superfamily which comprises proteins responsible for mediating cell-cell adhesion in a variety of tissues.

Biological function summary

This protein contributes to the regulation of cell adhesion and tissue morphogenesis. R Cadherin mediates homophilic interactions which means it binds to the same molecule on adjacent cells to maintain tissue architecture. It often forms a complex with catenins which link cadherins to the actin cytoskeleton. This interaction influences cell polarity migration and tissue maintenance impacting the development and maintenance of the nervous system and the eye.

Pathways

Many scientific studies place R Cadherin in the Wnt signaling pathway where it influences cellular proliferation and differentiation. It shows interaction with other cadherins like N-Cadherin part of the same superfamily each playing distinct roles in development processes by modulating cell adhesion properties important for proper pathway functioning. The protein interactions in these pathways help explain its role in cellular development and homeostasis.

Scientists have associated R Cadherin with cancer and retinal disorders. Aberrant expression or dysfunction of this protein can disrupt normal cell adhesion which can lead to tumor progression and metastasis. Furthermore it interacts with proteins like beta-catenin involved in both Wnt signaling and oncogenesis. Alterations in R Cadherin expression also relate to certain retinal degenerative diseases emphasizing its importance in maintaining structured tissue integrity and signaling.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

See full target information Cadherin-4

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

eLife 14: PubMed40938188

2025

Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the mouse anterior brainstem.

Applications

Unspecified application

Species

Unspecified reactive species

Sami Kilpinen,Lassi Virtanen,Silvana Bodington Celma,Amos Bonsdorff,Heidi Heliölä,Kaia Achim,Juha Partanen

Journal of Parkinson's disease 13:1303-1311 PubMed38143373

2023

Understanding the Role of CDH4 in Multiple System Atrophy Brain.

Applications

Unspecified application

Species

Unspecified reactive species

Finula I Isik,Jared S Katzeff,YuHong Fu,Woojin Scott Kim

Oncology letters 17:4819-4826 PubMed31186688

2019

MicroRNA-9 enhances chemotherapy sensitivity of glioma to TMZ by suppressing TOPO II via the NF-κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qingla Li,Yingnan Chang,Luyan Mu,Yuwen Song

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-R Cadherin 抗体 [EPR4836]

Anti-R Cadherin antibody [EPR4836]

Western blot - Anti-R Cadherin antibody [EPR4836] (AB109242)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

代替製品

Primary Antibodies

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise