AB228998

Anti-PYROXD2 抗体

Name: Anti-PYROXD2 抗体 (ab228998) | Abcam
Brand: Abcam Limited
SKU: AB228998
Price: 74000 JPY
Availability: InStock

Anti-PYROXD2 antibody

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(2 Publications)

Rabbit Polyclonal PYROXD2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PYROXD2.

別名を表示する

C10orf33, PYROXD2, Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

Paraffin-embedded human breast cancer tissue stained for PYROXD2 using ab228998 at 1/500 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-PYROXD2 antibody (AB228998)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-PYROXD2 antibody (ab228998) at 1/1000 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney) whole cell lysate at 30 µg

Lane 2:

Raji (Human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

Predicted band size: 63 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human PYROXD2. The exact immunogen used to generate this antibody is proprietary information.

Q8N2H3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PYROXD2 also known as Pyridine Nucleotide-Disulfide Oxidoreductase Domain 2 is a protein with a molecular weight of approximately 39 kDa. It functions mechanically as an oxidoreductase enzyme participating in redox reactions by facilitating the transfer of electrons. Expression of PYROXD2 is widespread but shows higher levels in tissues with elevated metabolic activities such as the liver kidney and heart. This widespread expression suggests its fundamental role in cellular processes that require redox homeostasis.

Biological function summary

PYROXD2 contributes to cellular redox balance and detoxification. It operates as part of a larger multi-enzyme complex involved in maintaining oxidative homeostasis in the cell. This function is important for protecting cells against oxidative stress which might lead to cellular damage and apoptosis. By regulating redox-sensitive pathways PYROXD2 helps maintain cellular health and function.

Pathways

PYROXD2 participates in significant biochemical networks focusing on redox regulation and electron transport. Notably the protein interacts within the glutathione metabolic pathway where it works alongside proteins like glutathione peroxidase and glutathione reductase to neutralize reactive oxygen species. PYROXD2 also relates to components of the mitochondrial respiratory chain linking it to important energy-production processes in the cell.

PYROXD2 shows associations with conditions involving oxidative stress including neurodegenerative diseases like Parkinson's Disease. Disrupted redox homeostasis is key in these pathologies where neurons are particularly susceptible to oxidative damage. Additionally PYROXD2 is linked to cardiovascular diseases where oxidative stress contributes to vascular inflammation and damage. These associations point to its potential as a therapeutic target particularly in diseases where oxidative stress plays a critical role.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Probable oxidoreductase that may play a role as regulator of mitochondrial function.

See full target information PYROXD2

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Immune network 23:e34 PubMed37670811

2023

Tumor Promoting Function of DUSP10 in Non-Small Cell Lung Cancer Is Associated With Tumor-Promoting Cytokines.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Wei,Chin Wen Png,Madhushanee Weerasooriya,Heng Li,Chenchen Zhu,Guiping Chen,Chuan Xu,Yongliang Zhang,Xiaohong Xu

International journal of molecular sciences 23: PubMed35055180

2022

Biallelic Variants in Cause a Severe Infantile Metabolic Disorder Affecting Mitochondrial Function.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole J Van Bergen,Daniella H Hock,Lucy Spencer,Sean Massey,Tegan Stait,Zornitza Stark,Sebastian Lunke,Ain Roesley,Heidi Peters,Joy Yaplito Lee,Anna Le Fevre,Oliver Heath,Cristina Mignone,Joseph Yuan-Mou Yang,Monique M Ryan,Colleen D'Arcy,Margot Nash,Sile Smith,Nikeisha J Caruana,David R Thorburn,David A Stroud,Susan M White,John Christodoulou,Natasha J Brown

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PYROXD2 抗体

Anti-PYROXD2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

Western blot - Anti-PYROXD2 antibody (AB228998)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

Abcam product promise