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AB89298

Anti-Puma gamma/GPR109A 抗体 [MM0329-6S24]

Anti-Puma gamma/GPR109A antibody [MM0329-6S24]

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(2 Publications)

Rat Monoclonal Puma gamma/GPR109A antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HCAR2.

別名を表示する

GPR109A, HCA2, HM74A, NIACR1, HCAR2, Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptor

1 Images
Western blot - Anti-Puma gamma/GPR109A antibody [MM0329-6S24] (AB89298)
  • WB

Supplier Data

Western blot - Anti-Puma gamma/GPR109A antibody [MM0329-6S24] (AB89298)

All lanes:

Western blot - Anti-Puma gamma/GPR109A antibody [MM0329-6S24] (ab89298) at 1/500 dilution

All lanes:

Human Placenta tissue lysate

Predicted band size: 42 kDa

false

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

MM0329-6S24

アイソタイプ

IgG2

キャリアフリー

No

交差種

Human

アプリケーション

WB, Flow Cyt

applications

免疫原

Recombinant Full Length Protein corresponding to Human HCAR2.

Q8TDS4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography.
バッファー組成
Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Puma gamma also known as GPR109A is a G-protein-coupled receptor with a molecular weight of approximately 39 kDa. This receptor is expressed in various tissues including adipose tissue the immune system and the gastrointestinal tract. Puma gamma is located on the cell surface where it binds to ligands including niacin and butyrate. Binding leads to changes in cellular activities through signaling specifically influencing cellular responses to external stimuli.
Biological function summary

GPR109A plays an important role in metabolic processes. This receptor is involved in the regulation of lipolysis in adipocytes thereby controlling fat breakdown. GPR109A is also significant in mediating anti-inflammatory responses. Although it does not form part of a larger complex its signaling affects interactions with other cellular components. These functions contribute to maintaining homeostasis within the body's systems.

Pathways

GPR109A participates in the cAMP signaling pathway which has importance in energy balance and hormone regulation. When GPR109A activates it inhibits adenylyl cyclase reducing cyclic AMP levels. This receptor is also linked to the anti-inflammatory pathways through interactions with cytokines and other immune-modulating proteins. GPR109A's activity connects closely with proteins such as beta-arrestins and GRK which modulate its signaling efficiency and duration.

GPR109A has associations with obesity and cardiovascular diseases. High levels of GPR109A expression or dysfunction can lead to increased inflammation contributing to metabolic syndrome and related health problems. This receptor's interaction with niacin is therapeutically targeted in managing dyslipidemia a risk factor for cardiovascular diseases. Additionally research indicates potential links between GPR109A and inflammatory bowel disease through modulation of immune cell activity.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
See full target information HCAR2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cells 13: PubMed38201291

2024

A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction.

Applications

Unspecified application

Species

Unspecified reactive species

Kenichi Aizawa,Akari Ikeda,Shota Tomida,Koki Hino,Yuuki Sugita,Tomoyasu Hirose,Toshiaki Sunazuka,Hiroshi Kido,Shigeyuki Yokoyama,Ryozo Nagai

Molecular nutrition & food research 66:e2200300 PubMed36208084

2022

GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaodi Zhang,Jiahong Li,Ming Zhang,Binbin Li,XiaoHua Pan,Xiaoliang Dong,Li-Long Pan,Jia Sun
View all publications
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代替製品

Primary Antibodies

AB198693

Anti-Puma gamma/GPR109A antibody

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  • 0
  • 0

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