JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB121620

Anti-PTCD1 抗体

Anti-PTCD1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal PTCD1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTCD1 aa 400-550.

別名を表示する

KIAA0632, PTCD1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTCD1 antibody (AB121620)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTCD1 antibody (AB121620)

ab121620 at 1/125 staining PTCD1 in Paraffin Embedded Human placenta tissue by Immunohistochemistry.
Note : strong cytoplasmic positivity in trophoblastic cells.

Western blot - Anti-PTCD1 antibody (AB121620)
  • WB

Unknown

Western blot - Anti-PTCD1 antibody (AB121620)

All lanes:

Western blot - Anti-PTCD1 antibody (ab121620) at 1/250 dilution

Lane 1:

RT4 lysate

Lane 2:

U 251 MG lysate

Lane 3:

Human plasma

Lane 4:

Human Liver lysate

Lane 5:

Human Tonsil lysate

Predicted band size: 79 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human PTCD1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

O75127

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PTCD1 also known as Pentatricopeptide Repeat Domain 1 is a mitochondrial protein involved in RNA processing. This protein has an approximate mass of 64 kDa. It is expressed in various tissues with significant levels found in the heart and skeletal muscles. PTCD1 is located within the mitochondria where it performs its mechanical functions related to RNA metabolism.
Biological function summary

PTCD1 participates in the stability and processing of mitochondrial RNA. It is an essential component of mitochondrial RNA metabolism interacting with RNA molecules to facilitate proper mitochondrial gene expression. PTCD1 does not appear to be part of a larger complex but it performs critical individual functions within the mitochondrial matrix.

Pathways

The protein PTCD1 plays a part in the mitochondrial gene expression pathway. It manages the processing and stability of mitochondrial mRNA which is necessary for the translation of mitochondrial protein-coding genes. PTCD1 is closely related to other mitochondrial RNA-binding proteins such as LRPPRC which also have roles in mRNA stability and expression.

PTCD1 has been connected to mitochondrial disorders particularly those linked with mitochondrial RNA processing defects. Its improper function can lead to mitochondrial myopathies which are disorders that affect muscle function due to mitochondrial dysfunction. PTCD1's role is important in understanding these conditions especially in relation to LRPPRC which shares overlapping functions in mitochondrial RNA metabolism.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs.
See full target information PTCD1
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed36446521

2022

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Flavia Roşianu,Simeon R Mihaylov,Noreen Eder,Antonie Martiniuc,Suzanne Claxton,Helen R Flynn,Shamsinar Jalal,Marie-Charlotte Domart,Lucy Collinson,Mark Skehel,Ambrosius P Snijders,Matthias Krause,Sharon A Tooze,Sila K Ultanir
View all publications
style
left-column
style
left-column
style
right-column

組合せ製品

Primary Antibodies

AB118800

Anti-ZZZ3 antibody

Immunoprecipitation - Anti-ZZZ3 antibody (AB118800)

  • 0
  • 0
Primary Antibodies

AB121685

Anti-ZNF750 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF750 antibody (AB121685)

  • 0
  • 0
Primary Antibodies

AB117837

Anti-ZNF787 antibody

Immunoprecipitation - Anti-ZNF787 antibody (AB117837)

  • 0
  • 0
Primary Antibodies

AB121804

Anti-ZNF704 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF704 antibody (AB121804)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com