Anti-PSPC1 抗体 (ab184123)
Key features and details
- Rabbit polyclonal to PSPC1
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-PSPC1 antibody
PSPC1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PSPC1 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Recombinant fragment within Human PSPC1 aa 1-176. The exact sequence is proprietary.
Database link: Q8WXF1 -
ポジティブ･コントロール
- 293T, HeLa and HepG2 whole cell lysates. Rat fore brain and mouse hind brain tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab184123の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
1/100 - 1/1000.
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| WB |
1/500 - 1/3000. Predicted molecular weight: 59 kDa.
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| 特記事項 |
|---|
|
IHC-P
1/100 - 1/1000. |
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WB
1/500 - 1/3000. Predicted molecular weight: 59 kDa. |
ターゲット情報
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機能
Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. -
組織特異性
Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. -
配列類似性
Belongs to the PSPC family.
Contains 2 RRM (RNA recognition motif) domains. -
翻訳後修飾
Phosphorylated upon DNA damage, probably by ATM or ATR. -
細胞内局在
Nucleus > nucleolus. Nucleus matrix. Cytoplasm. In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. - Information by UniProt
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参照データベース
- Entrez Gene: 55269 Human
- Entrez Gene: 66645 Mouse
- Entrez Gene: 305910 Rat
- Omim: 612408 Human
- SwissProt: Q8WXF1 Human
- SwissProt: Q8R326 Mouse
- SwissProt: Q4KLH4 Rat
- Unigene: 213198 Human
see all -
別名
- Paraspeckle component 1 antibody
- Paraspeckle protein 1 antibody
- PSP1 antibody
see all
画像
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Western blot - Anti-PSPC1 antibody (ab184123)All lanes : Anti-PSPC1 antibody (ab184123) at 1/2000 dilution
Lane 1 : 293T whole cell lysate
Lane 2 : Hela whole cell lysate
Lane 3 : HepG2 whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size: 59 kDa7.5% SDS PAGE
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSPC1 antibody (ab184123)Immunohistochemical analysis of paraffin-embedded rat fore brain labeling PSPC1 with ab184123 at 1/500 dilution
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSPC1 antibody (ab184123)Immunohistochemical analysis of paraffin-embedded mouse hind brain labeling PSPC1 with ab184123 at 1/500 dilution
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab184123 は 4 報の論文で使用されています。
- He H et al. The Prognosis Value of PSPC1 Expression in Nasopharyngeal Cancer. Cancer Manag Res 13:3281-3291 (2021). PubMed: 33883941
- Xu (徐兴丽) X et al. Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury. Arterioscler Thromb Vasc Biol 41:1428-1445 (2021). PubMed: 33626912
- Li S et al. The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein. Sci Rep 11:14001 (2021). PubMed: 34234233
- Pan YY et al. RNA-binding protein SFPQ cooperates with HDAC1 to suppress CD40 transcription in pulmonary adventitial fibroblasts. Cell Biol Int 44:166-176 (2020). PubMed: 31393052