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リコンビナントRabMAb

Anti-PSD95 (phospho S418) 抗体 [EPR2618Y] (ab76127)

Submit a review Submit a question References (1)
Western blot - Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127)
  • Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR2618Y] to PSD95 (phospho S418)
  • Suitable for: WB
  • Reacts with: Rat

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-PSD95 (phospho S418) antibody [EPR2618Y]
    PSD95 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR2618Y] to PSD95 (phospho S418)

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: WBmore details
    適用なし: Flow Cyt,ICC/IF,IHC-P or IP

  • 種交差性

    交差種: Rat
    交差が予測される動物種: Mouse, Human

  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ･コントロール

    • Rat brain tissue cell lysate.

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab76127の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB
1/500. Predicted molecular weight: 95 kDa.
特記事項
WB
1/500. Predicted molecular weight: 95 kDa.
追加情報
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

ターゲット情報

  • 機能

    Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.

  • 組織特異性

    Brain.

  • 配列類似性

    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 3 PDZ (DHR) domains.
    Contains 1 SH3 domain.

  • ドメイン

    The PDZ domain 3 mediates interaction with ADR1B.
    The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.

  • 翻訳後修飾

    Palmitoylation of isoform 1 is required for targeting to postsynaptic density.

  • 細胞内局在

    Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell junction, synapse. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • Discs large homolog 4 antibody
    • Disks large homolog 4 antibody
    • DLG 4 antibody
    • Dlg4 antibody
    • DLG4_HUMAN antibody
    • FLJ97752 antibody
    • FLJ98574 antibody
    • Human post synaptic density protein 95 antibody
    • Post synaptic density protein 95 antibody
    • Postsynaptic density protein 95 antibody
    • PSD 95 antibody
    • PSD-95 antibody
    • PSD95 antibody
    • SAP 90 antibody
    • SAP-90 antibody
    • SAP90 antibody
    • Synapse associated protein 90 antibody
    • Synapse-associated protein 90 antibody
    • Tax interaction protein 15 antibody
    see all

画像

  • Western blot - Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127)
    Western blot - Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127)
    All lanes : Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127) at 1/500 dilution

    Lane 1 : Rat brain tissue cell lysates, untreated
    Lane 2 : Rat brain tissue cell lysates, treated with AP

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : goat anti-rabbit-HRP at 1/1000 dilution

    Developed using the ECL technique.

    Predicted band size: 95 kDa
    Observed band size: 95 kDa

  • Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127)
    Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127)

参考文献 (1)

ab76127 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab76127 は 1 報の論文で使用されています。

  • Zhu YC  et al. Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development. Proc Natl Acad Sci U S A 110:9118-23 (2013). PubMed: 23671101

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