Anti-PSD93 抗体 [EPR8740] (ab151721)
![Western blot - Anti-PSD93 antibody [EPR8740] (ab151721)](https://www.abcam.co.jp/ps/products/151/ab151721/Images/ab151721-158784-anti-psd93-antibody-epr8740-western-blot.jpg "Western blot - Anti-PSD93 antibody [EPR8740] (ab151721)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR8740] to PSD93
- Suitable for: Flow Cyt (Intra), WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-PSD93 antibody [EPR8740]
PSD93 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR8740] to PSD93 -
由来種
Rabbit -
アプリケーション
適用あり: Flow Cyt (Intra), WBmore details
適用なし: ICC/IF or IHC-P -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ･コントロール
- HeLa, SH-SY5Y, Jurkat and Human astrocytoma cell lysates; SH-SY5Y cells.
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20ºC. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR8740 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab151721の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt (Intra) |
1/100 - 1/500.
ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. |
|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 97 kDa.
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| 特記事項 |
|---|
|
Flow Cyt (Intra)
1/100 - 1/500. ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. |
|
WB
1/1000 - 1/10000. Predicted molecular weight: 97 kDa. |
追加情報
Is unsuitable for ICC/IF or IHC-P.
ターゲット情報
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機能
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. -
配列類似性
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain. -
ドメイン
An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27. -
翻訳後修飾
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density. -
細胞内局在
Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Concentrated in soma and postsynaptic density of a subset of neurons. - Information by UniProt
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参照データベース
- Entrez Gene: 1740 Human
- Entrez Gene: 23859 Mouse
- Entrez Gene: 64053 Rat
- Omim: 603583 Human
- SwissProt: Q15700 Human
- SwissProt: Q91XM9 Mouse
- SwissProt: Q63622 Rat
- Unigene: 367656 Human
see all -
別名
- Channel associated protein of synapse 110 antibody
- Channel associated protein of synapses 110kD antibody
- Channel-associated protein of synapse-110 antibody
see all
画像
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Western blot - Anti-PSD93 antibody [EPR8740] (ab151721)All lanes : Anti-PSD93 antibody [EPR8740] (ab151721) at 1/1000 dilution
Lane 1 : HeLa cell lysate
Lane 2 : SH-SY5Y cell lysate
Lane 3 : Jurkat cell lysate
Lane 4 : Human astrocytoma cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat anti-rabbit HRP at 1/2000 dilution
Predicted band size: 97 kDa -
![Flow Cytometry (Intracellular) - Anti-PSD93 antibody [EPR8740] (ab151721)](https://www.abcam.co.jp/ps/products/151/ab151721/Images/ab151721-158783-anti-psd93-antibody-epr8740-flow-cytometry.jpg)
Flow Cytometry (Intracellular) - Anti-PSD93 antibody [EPR8740] (ab151721)Intracellular flow cytometric analysis of permeabilized SH-SY5Y cells labeling PSD93 with ab151721 at 1/100 dilution (red), compared to a nonspecific control antibody (green).
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![Anti-PSD93 antibody [EPR8740] (ab151721)](https://www.abcam.co.jp/ps/products/151/ab151721/Images/ab151721-3-benefits-of-recombinant-antibodies.png)
Anti-PSD93 antibody [EPR8740] (ab151721)
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab151721 は 3 報の論文で使用されています。
- Liu FR et al. Pedigree-based study to identify GOLGB1 as a risk gene for bipolar disorder. Transl Psychiatry 12:390 (2022). PubMed: 36115840
- Jian JM et al. Naturally-Occurring Antibodies Against Bim are Decreased in Alzheimer's Disease and Attenuate AD-type Pathology in a Mouse Model. Neurosci Bull 38:1025-1040 (2022). PubMed: 35570231
- Zhang Q et al. PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1. J Neurochem 157:2145-2157 (2021). PubMed: 33599284