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AB168220

Anti-Protocadherin 21 抗体

Anti-Protocadherin 21 antibody

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(2 Publications)

Mouse Polyclonal Protocadherin 21 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CDHR1.

別名を表示する

KIAA1775, PCDH21, PRCAD, CDHR1, Cadherin-related family member 1, Photoreceptor cadherin, Protocadherin-21, prCAD

1 Images
Western blot - Anti-Protocadherin 21 antibody (AB168220)
  • WB

Unknown

Western blot - Anti-Protocadherin 21 antibody (AB168220)

All lanes:

Western blot - Anti-Protocadherin 21 antibody (ab168220) at 1 µg/mL

Lane 1:

Protocadherin 21 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 94 kDa

false

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human CDHR1.

Q96JP9

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Protocadherin 21 also known as PCDH21 or retinal cadherin is a protein with a molecular mass of approximately 101 kDa. This protein is a member of the cadherin superfamily which is known for its role in cell-cell adhesion. PCDH21 is widely expressed in the retina notably in the photoreceptor cells which are critical for visual function. Its presence in these cells points to its significance in maintaining retinal structural integrity and potentially influencing cell signaling pathways necessary for visual processing.
Biological function summary

Protocadherin 21 contributes to the organization and connection of photoreceptors and is an integral component of the photoreceptor sensory cilium complex. This protein plays a role in the development and maintenance of the outer segment discs in photoreceptors which are essential for capturing light and initiating phototransduction. The organization and stability provided by PCDH21 assist in the photoreceptors' effective response to light stimulation emphasizing its importance in normal visual function.

Pathways

Photoreceptor cells rely heavily on the phototransduction cascade to convert light signals into neural signals a process in which Protocadherin 21 plays a supportive role. PCDH21 interacts with other retinal proteins such as rhodopsin which is important for the initiation of this cascade. Additionally links to the Wnt signaling pathway suggest a role in cellular communication and signal transduction highlighting PCDH21's broader interaction within cellular pathways important for proper retinal function.

Protocadherin 21 mutations have connections to inherited retinal diseases such as retinitis pigmentosa and cone-rod dystrophy. These conditions lead to progressive vision loss due to photoreceptor degeneration. Studies show that PCDH21 interacts with proteins like rhodopsin and mutations in either gene may disrupt normal photoreceptor function contributing to retinal degenerative processes. Understanding PCDH21's precise role in these diseases provides promises for targeted therapeutic strategies and better management of vision-related disorders.

製品プロトコール

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ターゲットの情報

Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).
See full target information CDHR1

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 12:606963 PubMed34054794

2021

Autoantibodies Against Ubiquitous and Confined Antigens in Patients With Ocular, Neuro-Ophthalmic and Congenital Cerebral Toxoplasmosis.

Applications

Unspecified application

Species

Unspecified reactive species

Monica Goldberg-Murow,Carlos Cedillo-Peláez,Luz Elena Concha-Del-Río,Rashel Cheja-Kalb,María José Salgar-Henao,Eduardo Orozco-Velasco,Héctor Luna-Pastén,Fernando Gómez-Chávez,Antonio Ibarra,Dolores Correa

Bioscience reports 39: PubMed31652447

2019

Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors.

Applications

Unspecified application

Species

Unspecified reactive species

Jiahui Li,Zhijie Liu,Liling Wang,Haiyan Xu,Yulin Wang
View all publications

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