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AB73948

Anti-Protein phosphatase 1 inhibitor subunit 2 抗体

Anti-Protein phosphatase 1 inhibitor subunit 2 antibody

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(1 Publication)

Rabbit Polyclonal Protein phosphatase 1 inhibitor subunit 2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PPP1R2.

別名を表示する

IPP2, PPP1R2, Protein phosphatase inhibitor 2, IPP-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Protein phosphatase 1 inhibitor subunit 2 antibody (AB73948)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Protein phosphatase 1 inhibitor subunit 2 antibody (AB73948)

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ab73948, at 1/50 dilution, in the presence (right panel) or absence (left panel) of immunising peptide.

Western blot - Anti-Protein phosphatase 1 inhibitor subunit 2 antibody (AB73948)
  • WB

Unknown

Western blot - Anti-Protein phosphatase 1 inhibitor subunit 2 antibody (AB73948)

All lanes:

Western blot - Anti-Protein phosphatase 1 inhibitor subunit 2 antibody (ab73948) at 1/500 dilution

Lane 1:

Extracts from Jurkat cells at 5 µg

Lane 2:

Extracts from Jurkat cells at 5 µg with immunising peptide

Predicted band size: 23 kDa

Observed band size: 25 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human PPP1R2. The exact immunogen used to generate this antibody is proprietary information.

P41236

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Stable for 12 months at -20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Protein Phosphatase 1 Inhibitor Subunit 2 often abbreviated as PPP1R2 functions as a regulatory protein that inhibits the activity of Protein Phosphatase 1 (PP1). PP1 is an important enzyme in various cellular processes including cell division and glycogen metabolism. PPP1R2 has a molecular mass of approximately 20 kDa. This inhibitory protein is ubiquitously expressed throughout different tissues indicating its role in fundamental cellular functions.
Biological function summary

PPP1R2 plays a critical role in cellular regulation by modulating PP1 activity. It forms a complex with PP1 in which PPP1R2 binds directly to the catalytic subunit of PP1 inhibiting its phosphatase activity. By controlling PP1 activity PPP1R2 impacts processes like muscle contraction protein synthesis and neuronal signaling making it an active participant in maintaining cellular homeostasis.

Pathways

PPP1R2 functions within important signaling and dephosphorylation pathways. It is notably involved in the glycogen metabolism pathway where it regulates PP1 activity influencing glycogen synthesis and breakdown. Additionally it participates in the cell cycle regulation pathway interacting with other proteins such as PP1 to control cell proliferation and division. The regulation of these pathways by PPP1R2 highlights its importance in key cellular activities.

PPP1R2's dysregulation can associate with several conditions. For instance alterations in PPP1R2 levels have implications in neurodegenerative diseases like Alzheimer's Disease since it affects neuronal protein dephosphorylation. Furthermore abnormal PPP1R2 expression can link to metabolic disorders including Type 2 Diabetes due to its role in glycogen metabolism. In these diseases its interaction with other proteins like PP1 and insulin signaling components is significant highlighting its potential as a therapeutic target.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Inhibitor of protein-phosphatase 1.
See full target information PPP1R2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in endocrinology 10:667 PubMed31632347

2019

The Interaction Between Nodal, Hypoxia-Inducible Factor 1 Alpha, and Thrombospondin 1 Promotes Luteolysis in Equine Corpus Luteum.

Applications

Unspecified application

Species

Unspecified reactive species

Edyta Walewska,Karolina Wołodko,Dariusz Skarzynski,Graça Ferreira-Dias,António Galvão
View all publications
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代替製品

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