AB231238

Anti-Prostate Specific Antigen 抗体

Name: Anti-Prostate Specific Antigen 抗体 (ab231238) | Abcam
Brand: Abcam Limited
SKU: AB231238
Price: 74000 JPY
Availability: InStock

Anti-Prostate Specific Antigen antibody

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(1 Publication)

Rabbit Polyclonal Prostate Specific Antigen antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Klk1b3 aa 1 to C-terminus.

別名を表示する

Klk-3, Klk3, Ngfg, Klk1b3, Kallikrein 1-related peptidase b3, 7S nerve growth factor gamma chain, Gamma-NGF, Glandular kallikrein K3, Tissue kallikrein-3, mGK-3

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody (AB231238)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody (AB231238)

Formalin-fixed, paraffin-embedded mouse liver tissue stained for Prostate Specific Antigen with ab231238 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Prostate Specific Antigen antibody (AB231238)

All lanes:

Western blot - Anti-Prostate Specific Antigen antibody (ab231238) at 2 µg/mL

All lanes:

Mouse kidney lysate

Predicted band size: 29 kDa

false

Supplier Data

Western blot - Anti-Prostate Specific Antigen antibody (AB231238)

All lanes:

Western blot - Anti-Prostate Specific Antigen antibody (ab231238) at 2 µg/mL

All lanes:

Mouse liver lysate

Predicted band size: 29 kDa

false

Supplier Data

Western blot - Anti-Prostate Specific Antigen antibody (AB231238)

All lanes:

Western blot - Anti-Prostate Specific Antigen antibody (ab231238) at 2 µg/mL

All lanes:

Recombinant mouse Prostate Specific Antigen protein

Predicted band size: 29 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Mouse Klk1b3 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P00756

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

ab231238 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

バッファー組成

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Prostate Specific Antigen (PSA) also known as kallikrein-related peptidase 3 (KLK3) is a serine protease with a mass of approximately 28.4 kDa. PSA is primarily expressed in the epithelial cells of the prostate gland. This glycoprotein is an important component in the seminal fluid where it performs its proteolytic activity that liquefies semen facilitating sperm motility.

Biological function summary

PSA functions by cleaving the gel-forming proteins present in seminal coagulum. It does not operate as part of a larger protein complex. PSA also interacts with substrates like fibronectin and semenogelin which play roles in seminal coagulation and liquefaction. The expression of PSA in prostate tissue has made it a valuable biomarker for prostate function and pathological conditions.

Pathways

PSA is involved in the kallikrein-kinin system which influences inflammation and blood pressure regulation. PSA is not directly a part of key metabolic or signaling pathways but it is co-expressed with key proteins like androgen receptor (AR) which modulates PSA's expression. The interplay between androgens and PSA highlights its role in hormone regulation within the male reproductive system.

PSA levels serve as an indicator for prostate cancer and benign prostatic hyperplasia (BPH). Elevated PSA levels often correlate with prostate cancer although other prostate conditions such as prostatitis can also increase PSA without cancer. Proteins like PCA3 and the AR are also connected in the context of prostate cancer providing a broader understanding of PSA's role in these diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

7S NGF alpha chain stabilizes the 7S complex. The beta dimer promotes neurite growth. The gamma chain is an arginine-specific protease; it may also have plasminogen activator activity, as well as mitogenic activity for chick embryo fibroblasts.

See full target information Klk1b3

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical and translational hepatology 12:496-504 PubMed38779522

2024

The Therapeutic Effects of Baicalein on the Hepatopulmonary Syndrome in the Rat Model of Chronic Common Bile Duct Ligation.

Applications

Unspecified application

Species

Unspecified reactive species

Ziyang Zeng,Yuhao Lei,Chunyong Yang,Xianfeng Wu,Liang Zhang,Zhiyong Yang,Lin Chen,Xiaobo Wang,Karine Belguise,Yujie Li,Bin Yi

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Prostate Specific Antigen 抗体

Anti-Prostate Specific Antigen antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody (AB231238)

Western blot - Anti-Prostate Specific Antigen antibody (AB231238)

Western blot - Anti-Prostate Specific Antigen antibody (AB231238)

Western blot - Anti-Prostate Specific Antigen antibody (AB231238)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

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Abcam product promise