Anti-Properdin/PFC 抗体 (ab186834)
Key features and details
- Rabbit polyclonal to Properdin/PFC
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Properdin/PFC antibody
Properdin/PFC 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Properdin/PFC -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, WB, IHC-Pmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Recombinant full length protein corresponding to Human Properdin/PFC aa 1-469.
Database link: P27918 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.30
Preservative: 0.05% Proclin 300
Constituents: 49.95% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab186834の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF |
Use at an assay dependent concentration.
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| WB |
1/500 - 1/2000. Predicted molecular weight: 51 kDa.
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| IHC-P |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
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ICC/IF
Use at an assay dependent concentration. |
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WB
1/500 - 1/2000. Predicted molecular weight: 51 kDa. |
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IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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機能
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. -
関連疾患
Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III). -
配列類似性
Contains 6 TSP type-1 domains. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 5199 Human
- Entrez Gene: 18636 Mouse
- Entrez Gene: 299314 Rat
- Omim: 300383 Human
- SwissProt: P27918 Human
- SwissProt: P11680 Mouse
- Unigene: 53155 Human
- Unigene: 3064 Mouse
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別名
- BFD antibody
- CFP antibody
- Complement factor P antibody
see all
画像
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Immunocytochemistry/ Immunofluorescence - Anti-Properdin/PFC antibody (ab186834)Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186834. Blue DAPI for nuclear staining.
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Western blot - Anti-Properdin/PFC antibody (ab186834)All lanes : Anti-Properdin/PFC antibody (ab186834) at 1/500 dilution
Lane 1 : Extracts from 293T cell line
Lane 2 : Extracts from 3T3L1 cell line
Lane 3 : Extracts from mouse liver
Lane 4 : Extracts from mouse brain
Lane 5 : Extracts from mouse kidney
Predicted band size: 51 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab186834 は 1 報の論文で使用されています。
- Wu Y et al. Properdin Deficiency Impairs Phagocytosis and Enhances Injury at Kidney Repair Phase Post Ischemia-Reperfusion. Front Immunol 12:697760 (2021). PubMed: 34552582