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AB17780

Anti-Properdin/PFC 抗体 [10C5]

Anti-Properdin/PFC antibody [10C5]

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(2 Publications)

Mouse Monoclonal Properdin/PFC antibody. Suitable for ELISA, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CFP.

別名を表示する

PFC, CFP, Properdin, Complement factor P

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

10C5

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Human

アプリケーション

ELISA, WB

applications

免疫原

Native Full Length Protein corresponding to Human CFP.

P27918

特異性

To be determined.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Properdin also known as factor P or complement factor P plays an essential role in the immune system. It is a serum protein with a molecular mass of approximately 53 kDa. Properdin is most commonly expressed in monocytes neutrophils and activated macrophages. It serves as a positive regulator in the alternative pathway of the complement system providing stability to the complement convertase complexes C3bBb and C3bBbC3b.
Biological function summary

Properdin enhances the activity of the complement system by stabilizing the C3 and C5 convertase enzyme complexes. These complexes are critical in the amplification of the complement cascade leading to pathogen opsonization and lysis. Properdin does not form part of a complex alone but helps existing complement complexes carry out their functions more effectively. By supporting these complexes properdin contributes to immune surveillance and the host's response to microbial invaders.

Pathways

Properdin operates within the alternative complement pathway and plays a pivotal role in immune defense. It interacts with other components such as C3 and C5 contributing to the pathway's ability to clear pathogens and damaged cells. Properdin's activity also indirectly influences other related proteins in the complement system supporting a coordinated immune response that involves factors beyond the alternative pathway itself.

Properdin deficiencies or dysregulations can lead to increased susceptibility to infections particularly by Neisseria species accounting for recurrent meningococcal disease. Additionally abnormal properdin function links to autoimmune conditions such as systemic lupus erythematosus. This connection is due to its relationship with various complement factors such as C3 which are vital for maintaining immune homeostasis.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

A positive regulator of the alternate pathway (AP) of complement (PubMed : 16301317, PubMed : 20382442, PubMed : 28264884, PubMed : 9748277). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed : 16301317, PubMed : 20382442, PubMed : 28264884, PubMed : 9748277). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed : 31507604).
See full target information CFP
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cell chemical biology 28:14-25.e9 PubMed33176158

2020

Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade.

Applications

Unspecified application

Species

Unspecified reactive species

A Katherine Hatstat,Hannah D Ahrendt,Matthew W Foster,Leland Mayne,M Arthur Moseley,S Walter Englander,Dewey G McCafferty

Oncology reports 39:2279-2287 PubMed29498404

2018

Deleted in malignant brain tumor 1 is a novel prognostic marker in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Heae Surng Park,Byung Chang Kim,Hyun Yang Yeo,Kyung-Hee Kim,Byong Chul Yoo,Ji Won Park,Hee Jin Chang
View all publications
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代替製品

Proteins & Peptides

AB180316

Recombinant Human Properdin/PFC protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Properdin/PFC protein (denatured) (His tag N-Terminus) (AB180316)

  • 0
  • 0
Primary Antibodies

AB58984

Anti-Properdin/PFC antibody [10-18]

  • 0
  • 0
Primary Antibodies

AB252531

Anti-Properdin/PFC antibody [3A3E1]

Recombinant|Trial Size

Flow Cytometry (Intracellular) - Anti-Properdin/PFC antibody [3A3E1] (AB252531)

  • 0
  • 0
Primary Antibodies

AB254275

Anti-Properdin/PFC antibody [3A3E1] - BSA and Azide free

Recombinant

Flow Cytometry (Intracellular) - Anti-Properdin/PFC antibody [3A3E1] - BSA and Azide free (AB254275)

  • 0
  • 0

組合せ製品

Assay Kits

AB316252

Human Properdin/PFC ELISA Kit

SimpleStep|Recombinant

Sandwich ELISA - Human Properdin/PFC ELISA Kit (AB316252)

  • 0
  • 0
Primary Antibodies

AB275931

Anti-C5 / C5b antibody [EPR23940-3]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5 / C5b antibody [EPR23940-3] (AB275931)

  • 0
  • 0
Primary Antibodies

AB309149

Anti-Complement factor B antibody [EPR27443-6]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Complement factor B antibody [EPR27443-6] (AB309149)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB32412

Anti-C Reactive Protein antibody [Y284]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C Reactive Protein antibody [Y284] (AB32412)

  • 5
  • 6

Abcam product promise

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