AB118492

Anti-Prominin 2 抗体

Name: Anti-Prominin 2 抗体 (ab118492) | Abcam
Brand: Abcam Limited
SKU: AB118492
Price: 90000 JPY
Availability: InStock

Anti-Prominin 2 antibody

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(2 Publications)

Rabbit Polyclonal Prominin 2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PROM2 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

PROML2, UNQ2521/PRO6014, PROM2, Prominin-2, PROM-2, Prominin-like protein 2, hPROML2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)

ab118492 at 0.5 μg/ml staining Prominin 2 in Human Lung, Respiratory Epithelium by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)

ab118492 at 0.5 µg/ml staining Prominin 2 in Human Uterus by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human PROM2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8N271

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "15-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Prominin-2 also known as PROM2 is a transmembrane glycoprotein weighing approximately 124 kDa. It is part of the prominin family and is mainly expressed in epithelial cells of various tissues including the kidney pancreas and intestine. Mechanically Prominin-2 is involved in the organization of membrane protrusions due to its ability to bind to cholesterol. It localizes to plasma membrane sites and plays a role in maintaining cell morphology.

Biological function summary

Prominin-2 participates in several processes involving cellular differentiation and maintenance. It does not form a part of any known complex but interacts with cellular membranes to influence lipid composition. Prominin-2 facilitates cellular processes like epithelial cell polarity and is implicated in maintaining stem cell populations. Its association with membrane structures is key to its function in these contexts.

Pathways

Prominin-2 acts in cellular polarity and wound healing pathways. In the polarity pathway Prominin-2 associates with proteins like CDC42 essential for establishing asymmetry in cells. Within wound healing it interacts with the MAPK signaling pathway where its involvement affects cell migration and repair mechanisms. These pathways underline the role of Prominin-2 in maintaining epithelial integrity and repair.

Research links Prominin-2 to certain forms of cancer and retinal degeneration. In cancer Prominin-2 promotes tumorigenic potential by influencing cancer cell stemness and resistance to apoptosis. Connections to cancer-related proteins like CD133 highlight its role in tumor biology. In retinal degeneration alterations in Prominin-2 expression correlate with visual impairment possibly through disruptions in retinal epithelial cell structure.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information PROM2

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Radiology and oncology 57:325-336 PubMed37665741

2023

Prominin 2 decreases cisplatin sensitivity in non-small cell lung cancer and is modulated by CTCC binding factor.

Applications

Unspecified application

Species

Unspecified reactive species

Jiyang Tang,Dejun Shu,Zhimin Fang,Gaolan Yang

Andrology 2:559-71 PubMed24782439

2014

Effects of the oestrogen receptor antagonist Fulvestrant on expression of genes that affect organization of the epididymal epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

M F N Pereira,S A F Fernandes,A R Nascimento,E R Siu,R A Hess,C A Oliveira,C S Porto,M F M Lazari

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Prominin 2 抗体

Anti-Prominin 2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise