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AB187296

Anti-Progesterone Receptor 抗体 [PR501]

Anti-Progesterone Receptor antibody [PR501]

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(2 Publications)

Mouse Monoclonal Progesterone Receptor antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PGR.

別名を表示する

NR3C3, PGR, Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody [PR501] (AB187296)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody [PR501] (AB187296)

Immunohistochemical analysis of paraffin-embedded Human invasive ductal carcinoma tissue labeling Progesterone Receptor with ab187296 at 1 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody [PR501] (AB187296)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody [PR501] (AB187296)

Immunohistochemical analysis of paraffin-embedded Human breast tissue labeling Progesterone Receptor with ab187296 at 1 μg/ml.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

PR501

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human PGR. The exact immunogen used to generate this antibody is proprietary information.

P06401

特異性

ab187296 is specific to Progesterone Receptor and shows minimal cross-reaction with other members of the family.

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代替製品

Primary Antibodies

AB101688

Anti-Progesterone Receptor antibody [SP42]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody [SP42] (AB101688)

  • 5
  • 2
Primary Antibodies

AB32085

Anti-Progesterone Receptor antibody [YR85]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Progesterone Receptor antibody [YR85] (AB32085)

  • 4
  • 5
Primary Antibodies

AB206926

Anti-Progesterone Receptor antibody [YR85] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Progesterone Receptor antibody [YR85] - BSA and Azide free (AB206926)

  • 0
  • 0
Primary Antibodies

AB75857

Anti-Progesterone Receptor (phospho S190) antibody [EP1516Y]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor (phospho S190) antibody [EP1516Y] (AB75857)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB183311

Anti-C4d antibody [SP91] - C-terminal

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C4d antibody [SP91] - C-terminal (AB183311)

  • 5
  • 1
Primary Antibodies

AB108398

Anti-Estrogen Receptor alpha antibody [EPR4097]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-Estrogen Receptor alpha antibody [EPR4097] (AB108398)

  • 5
  • 12
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB16662

Anti-ErbB2 / HER2 antibody [SP3]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB2 / HER2 antibody [SP3] (AB16662)

  • 5
  • 2
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The progesterone receptor (PR) also known as NR3C3 is a nuclear receptor that functions as a transcription factor in response to the hormone progesterone. This receptor has a mass of approximately 99 kDa and is expressed in tissues such as the reproductive organs including the uterus ovaries and mammary glands. It is also found in non-reproductive tissues like the brain and bone. The receptor has two main isoforms PR-A and PR-B which differ slightly in structure but have unique biological roles.
Biological function summary

The progesterone receptor plays a significant role in regulating gene expression related to reproductive processes. PR is not part of a larger complex by itself but interacts with various coactivators and corepressors to modulate transcription. In the uterus and mammary glands PR mediates the effects of progesterone by promoting cell proliferation and preparing tissues for pregnancy. In other systems PR also links to various metabolic and immunological pathways influencing cell cycle progression and immune response.

Pathways

Progesterone receptor activity is integrated within the reproductive hormone signaling pathways and the Wnt signaling pathway. The receptor interacts directly with key proteins such as estrogen receptor (ER) and steroid receptor coactivator (SRC) complexes which are pivotal in modulating response to hormonal signals. These interactions underline the essential role of PR in maintaining hormonal balance and regulating reproductive functions.

The progesterone receptor associates with breast cancer and endometriosis. Aberrant expression or mutations in PR can contribute to the development and progression of breast cancer often linked with the estrogen receptor's influence. In endometriosis PR's altered functionality affects cellular response to progesterone contributing to tissue growth outside the uterus. These conditions also involve interactions with proteins like BRCA1 in breast cancer highlighting how PR connects to broader cellular and pathological networks.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor.. Isoform A. Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.. Isoform B. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.. Isoform 4. Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
See full target information PGR
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

American journal of reproductive immunology (New York, N.Y. : 1989) 93:e70054 PubMed39918432

2025

The Effect of Acupoint Sticking Therapy on Serum Estrogen Levels and Endometrial Polyp Tissue Receptor Expression in Postmenopausal Patients With Endometrial Polyps.

Applications

Unspecified application

Species

Unspecified reactive species

Da Zhang,Ying Chen,Liangyu Zhang,Yang Wang

Oncoscience 5:75-87 PubMed29854876

2018

Plasma-derived Exosomes Reverse Epithelial-to-Mesenchymal Transition after Photodynamic Therapy of Patients with Head and Neck Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Marie-Nicole Theodoraki,Saigopalakrishna S Yerneni,Cornelia Brunner,Joannis Theodorakis,Thomas K Hoffmann,Theresa L Whiteside
View all publications
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