Anti-Progesterone Receptor 抗体 [PGR/2694]
Anti-Progesterone Receptor antibody [PGR/2694]
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Mouse Monoclonal Progesterone Receptor antibody. Suitable for Protein Array, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PGR aa 450 to C-terminus.
別名を表示する
NR3C3, PGR, Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody [PGR/2694] (AB268102)
Formalin-fixed, paraffin-embedded human endometrial carcinoma tissue stained for Progesterone Receptor using ab268102 at 2 μg/ml in immunohistochemical analysis.
- Protein Array
Unknown
Protein Array - Anti-Progesterone Receptor antibody [PGR/2694] (AB268102)
Protein Array containing more than 19,000 full-length human proteins using ab268102.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.
Reactivity data
出荷温度及び保存条件
製品の状態
精製方法
精製に関する特記事項
バッファー組成
出荷温度
短期保存期間
短期保存温度
長期保存温度
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保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The progesterone receptor plays a significant role in regulating gene expression related to reproductive processes. PR is not part of a larger complex by itself but interacts with various coactivators and corepressors to modulate transcription. In the uterus and mammary glands PR mediates the effects of progesterone by promoting cell proliferation and preparing tissues for pregnancy. In other systems PR also links to various metabolic and immunological pathways influencing cell cycle progression and immune response.
Pathways
Progesterone receptor activity is integrated within the reproductive hormone signaling pathways and the Wnt signaling pathway. The receptor interacts directly with key proteins such as estrogen receptor (ER) and steroid receptor coactivator (SRC) complexes which are pivotal in modulating response to hormonal signals. These interactions underline the essential role of PR in maintaining hormonal balance and regulating reproductive functions.
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