Anti-ProDynorphin 抗体 (ab11137)
Key features and details
- Rabbit polyclonal to Dynorphin B
- Suitable for: IHC-Fr
- Reacts with: Mouse, Rat
- Isotype: IgG
製品の概要
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製品名
Anti-ProDynorphin antibody -
製品の詳細
Rabbit polyclonal to Dynorphin B -
由来種
Rabbit -
特異性
This antibody blocks specifically with leumorphin (rat only). Cells are found in the paraventricular and supraoptic nucleus and fibres in the lateral hypothalamus in rat brain of colchicine treated 4% FA perfused tissue. -
アプリケーション
適用あり: IHC-Frmore details -
種交差性
交差種: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Rat ProDynorphin.
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特記事項
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA, 5% Sucrose -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab11137の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-Fr |
1/100 - 1/2000.
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特記事項 |
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IHC-Fr
1/100 - 1/2000. |
ターゲット情報
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機能
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect. -
関連疾患
Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. -
配列類似性
Belongs to the opioid neuropeptide precursor family. -
翻訳後修飾
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 18610 Mouse
- Entrez Gene: 29190 Rat
- SwissProt: O35417 Mouse
- SwissProt: P06300 Rat
- Unigene: 6239 Mouse
- Unigene: 44471 Rat
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別名
- Beta-neoendorphin-dynorphin antibody
- Big Dyn antibody
- Dyn B antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab11137 は 5 報の論文で使用されています。
- Lee GJ et al. Anterior Insular-nucleus Accumbens Pathway Controls Refeeding-induced Analgesia under Chronic Inflammatory Pain Condition. Neuroscience 495:58-73 (2022). PubMed: 35643248
- Liu L et al. Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy. Cell Biol Int 46:1814-1824 (2022). PubMed: 35989483
- Whitfield TW et al. ? Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci 35:4296-305 (2015). PubMed: 25762676
- Romero-Picó A et al. Hypothalamic ?-opioid receptor modulates the orexigenic effect of ghrelin. Neuropsychopharmacology 38:1296-307 (2013). PubMed: 23348063
- Schlosburg JE et al. Long-term antagonism of ? opioid receptors prevents escalation of and increased motivation for heroin intake. J Neurosci 33:19384-92 (2013). Rat . PubMed: 24305833