Anti-proBNP 抗体 [5B6] (ab13111)
Key features and details
- Mouse monoclonal [5B6] to proBNP
- Suitable for: ELISA, WB
- Reacts with: Recombinant fragment
- Isotype: IgG1
製品の概要
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製品名
Anti-proBNP antibody [5B6]
proBNP 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [5B6] to proBNP -
由来種
Mouse -
アプリケーション
適用あり: ELISA, WBmore details -
種交差性
交差種: Recombinant fragment -
免疫原
Synthetic peptide:
HPLGSPGSASDL
, corresponding to amino acids 1 - 12 of Human proBNP. -
特記事項
This product has switched from ascites to TCS on 10th June 2020.
Immunoglobulin concentrations vary from batch to batch (generally 4-6 mg/ml for this clone). Please contact technical services for the latest information.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.1% Sodium azide -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
5B6 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab13111の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration. Detects a band of approximately 13 kDa.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Detects a band of approximately 13 kDa. |
ターゲット情報
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機能
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
組織特異性
Brain and also in atria, but at much lower levels than ANP. -
配列類似性
Belongs to the natriuretic peptide family. -
細胞内局在
Secreted. - Information by UniProt
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別名
- ANFB_HUMAN antibody
- BNP antibody
- BNP(1-32) antibody
see all
画像
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WB detecting proBNP showing comparable detection from a range of antibodies available. Lane 1 - ab13111 [5B6], lane 2 - ab13115 [15F11], lane 3 - ab13059 [11D1], lane 4 - ab13124 [15D7], lane 5 - ab13122 [13C1], lane 6 ab13123 [24E11]. WB detecting proBNP showing comparable detection from a range of antibodies available. Lane 1 - ab13111 [5B6], lane 2 - ab13115 [15F11], lane 3 - ab13059 [11D1], lane 4 - ab13124 [15D7], lane 5 - ab13122 [13C1], lane 6 ab13123 [24E11].
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab13111 は 4 報の論文で使用されています。
- Hsu A et al. Targeting transcription in heart failure via CDK7/12/13 inhibition. Nat Commun 13:4345 (2022). PubMed: 35896549
- Hsu A et al. Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. J Clin Invest 130:2966-2977 (2020). PubMed: 32106109
- Duan Q et al. BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Sci Transl Med 9:N/A (2017). PubMed: 28515341
- Carlson C et al. Phenotypic Screening with Human iPS Cell-Derived Cardiomyocytes: HTS-Compatible Assays for Interrogating Cardiac Hypertrophy. J Biomol Screen N/A:N/A (2013). PubMed: 24071917