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AB168134

Anti-PRMT8 抗体

Anti-PRMT8 antibody

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(1 Publication)

Mouse Polyclonal PRMT8 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PRMT8.

別名を表示する

HRMT1L3, HRMT1L4, PRMT8, Protein arginine N-methyltransferase 8, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

1 Images
Western blot - Anti-PRMT8 antibody (AB168134)
  • WB

Unknown

Western blot - Anti-PRMT8 antibody (AB168134)

All lanes:

Western blot - Anti-PRMT8 antibody (ab168134) at 1 µg/mL

Lane 1:

PRMT8 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 45 kDa

false

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human PRMT8.

Q9NR22

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein arginine methyltransferase 8 commonly referred to as PRMT8 catalyzes the transfer of methyl groups to arginine residues on target proteins. It is part of the PRMT family and possesses a molecular mass of approximately 42 kDa. PRMT8 shares sequence similarity with PRMT1 but shows unique tissue-specific expression. Notably it is mainly found in the brain where it localizes to the plasma membrane suggesting specialized functions in neuronal cells.
Biological function summary

PRMT8 contributes to modulating signal transduction pathways in neurons. It plays a role in the post-translational modification of proteins which affects their interaction and stability. Though not known to form any stable large complexes PRMT8's methyltransferase activity modifies substrate proteins influencing their cellular functions. In neurons this activity may regulate synaptic plasticity or neural communication through methylation of proteins involved in signal transduction.

Pathways

Arginine methylation by PRMT8 influences several key signaling pathways including the phosphoinositide and protein kinase pathways. PRMT8's activity affects proteins such as Src family kinases which are important in transmitting signals for cell growth and differentiation. Interaction with these pathways suggests that PRMT8 serves as a modulator of complex cellular signaling mechanisms balancing neuronal response and adaptation.

Abnormalities in PRMT8 activity have associations with neurodegenerative diseases and brain-related disorders including Alzheimer's disease. Dysregulation of PRMT8 may affect amyloid precursor protein processing implicating its role along with proteins such as tau in disease pathology. Understanding PRMT8's involvement in these conditions could inform therapeutic strategies that target arginine methylation to ameliorate or prevent disease progression.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed : 16051612, PubMed : 17925405, PubMed : 26529540, PubMed : 26876602). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed : 18320585).
See full target information PRMT8
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of autoimmunity 97:10-21 PubMed30318155

2018

Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yuki Kagoya,Hiroshi Saijo,Yukiko Matsunaga,Tingxi Guo,Kayoko Saso,Mark Anczurowski,Chung-Hsi Wang,Kenji Sugata,Kenji Murata,Marcus O Butler,Cheryl H Arrowsmith,Naoto Hirano
View all publications
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